{"id":"W4376573510","doi":"10.1089/scd.2022.0283","title":"Deletion of <i>p66Shc</i> Dysregulates ERK and STAT3 Activity in Mouse Embryonic Stem Cells, Enhancing Their Naive-Like Self-Renewal in the Presence of Leukemia Inhibitory Factor","year":2023,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"","keywords":"MAPK/ERK pathway; Biology; Leukemia inhibitory factor; Cell biology; Embryonic stem cell; Signal transduction; STAT3; Stem cell; Transcription factor; Kinase; STAT protein; Cellular differentiation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001340941,0.0005356264,0.0001834624,0.0003359434,0.0001446032,0.0002990419,0.0002030456,0.0002962425,0.001549026],"category_scores_gemma":[0.00007740602,0.0002647828,0.0002912581,0.0002164181,0.0003819712,0.000156629,0.0002013362,0.0006034252,0.0005206716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002831473,"about_ca_system_score_gemma":0.0001998975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006656586,"about_ca_topic_score_gemma":0.001030793,"domain_scores_codex":[0.9997603,0.0000266705,0.00004063855,0.00004987446,0.0000689377,0.00005359722],"domain_scores_gemma":[0.9997992,0.0000212652,0.00007334754,0.00002384434,0.00001023813,0.00007211391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004576091,0.00001197756,0.00008077354,0.00001092276,0.000002440453,0.00002529272,0.000005046869,0.00003697554,0.9994237,0.00007026078,0.00001298409,0.0002739485],"study_design_scores_gemma":[0.00001754572,0.0001553813,0.003874918,0.000003886331,0.00001459649,0.0001573758,0.00001762016,0.0008608063,0.9935001,0.00003497925,0.001358847,0.000003990664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951203,0.0004409082,0.00224872,0.00007173038,0.00002674144,0.00003341163,0.0007927712,0.0001445925,0.001120762],"genre_scores_gemma":[0.9947836,0.0003557099,0.001430558,0.00004066313,0.000008592804,0.0000443068,0.0007345065,0.00004032857,0.002561859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001549026,"threshold_uncertainty_score":0.005182028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01361763883769324,"score_gpt":0.2258781332837942,"score_spread":0.2122604944461009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}