{"id":"W4376573510","doi":"10.1089/scd.2022.0283","title":"Deletion of <i>p66Shc</i> Dysregulates ERK and STAT3 Activity in Mouse Embryonic Stem Cells, Enhancing Their Naive-Like Self-Renewal in the Presence of Leukemia Inhibitory Factor","year":2023,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"","keywords":"MAPK/ERK pathway; Biology; Leukemia inhibitory factor; Cell biology; Embryonic stem cell; Signal transduction; STAT3; Stem cell; Transcription factor; Kinase; STAT protein; Cellular differentiation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006667023,0.0001999468,0.0002603718,0.0001317509,0.00006409937,0.00002184732,0.00019218,0.0001445048,0.000001681214],"category_scores_gemma":[0.00000339577,0.0001538967,0.00003363633,0.0002150554,0.00008875941,0.00001301913,0.0002957064,0.000141056,0.000002113984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007673324,"about_ca_system_score_gemma":0.0003405119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008462959,"about_ca_topic_score_gemma":0.0003658407,"domain_scores_codex":[0.9983706,0.0002137979,0.0003583239,0.0004087789,0.0002951108,0.0003534215],"domain_scores_gemma":[0.9993882,0.0001083175,0.0001399294,0.0002387332,0.00005943432,0.00006538726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008360833,0.00006478299,0.003460916,0.0004034735,0.00003033532,0.000005695123,0.002252883,0.0001696204,0.9900402,0.000002105664,0.00008679037,0.003399602],"study_design_scores_gemma":[0.000564035,0.0001080532,0.006103789,0.0000836227,0.000002900182,0.000002117797,0.001401459,0.0001803069,0.9904366,0.000004677665,0.0009477362,0.0001646701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985633,0.0007589172,0.00004644598,0.00001878286,0.00007337558,0.0004453066,0.00003374046,0.00001005035,0.000050051],"genre_scores_gemma":[0.9978206,0.001531652,0.0001243481,0.00001265862,0.00001446064,0.00003220875,0.0000131127,0.00001687902,0.0004341236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003234932,"threshold_uncertainty_score":0.6275727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01361763883769324,"score_gpt":0.2258781332837942,"score_spread":0.2122604944461009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}