{"id":"W4376598275","doi":"10.1016/j.gene.2023.147477","title":"The transcription factors Creb1 and CEBPB regulate Sox9 promoter activity in TM4 Sertoli cells","year":2023,"lang":"en","type":"article","venue":"Gene","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital; Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation","keywords":"Biology; SOX9; Sertoli cell; Transcription factor; Genetics; Transcription (linguistics); Promoter activity; Promoter; Cell biology; Computational biology; Gene; Endocrinology; Gene expression; Spermatogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001472326,0.0001741508,0.0002463376,0.0004831324,0.0002257844,0.0002874098,0.0002741315,0.0002619377,0.002665283],"category_scores_gemma":[0.0002967267,0.0002111299,0.0002041996,0.0001673828,0.000463797,0.000187728,0.0002377162,0.000552036,0.0005439174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003628342,"about_ca_system_score_gemma":0.0003297318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002177693,"about_ca_topic_score_gemma":0.002208598,"domain_scores_codex":[0.9998511,0.0000257567,0.000009711847,0.00002650777,0.00004417862,0.0000426872],"domain_scores_gemma":[0.9997773,0.0000314891,0.00004719339,0.0000186806,0.00003660432,0.0000887529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001528988,0.00000856555,0.0006581672,0.00001292818,0.000002417497,0.0000673332,0.00002439875,0.00001844481,0.9984055,0.000106151,0.00002413078,0.0005190647],"study_design_scores_gemma":[0.00002906725,0.0001407193,0.04572347,0.0000101104,0.00001261831,0.00106861,0.0001484145,0.001196798,0.9493794,0.0001778448,0.002105727,0.000007189705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933875,0.001174779,0.003381382,0.0001433042,0.00002340823,0.0000114058,0.0004273681,0.00008418829,0.001366563],"genre_scores_gemma":[0.9944531,0.0002185714,0.001138847,0.00003589976,0.00001284814,0.0000160967,0.0005199104,0.0000404908,0.003564316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002665283,"threshold_uncertainty_score":0.008916259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528267622301665,"score_gpt":0.2498555636611653,"score_spread":0.2345728874381487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}