{"id":"W4376598275","doi":"10.1016/j.gene.2023.147477","title":"The transcription factors Creb1 and CEBPB regulate Sox9 promoter activity in TM4 Sertoli cells","year":2023,"lang":"en","type":"article","venue":"Gene","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital; Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation","keywords":"Biology; SOX9; Sertoli cell; Transcription factor; Genetics; Transcription (linguistics); Promoter activity; Promoter; Cell biology; Computational biology; Gene; Endocrinology; Gene expression; Spermatogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478315,0.0001024119,0.00009005108,0.0000219186,0.0001123821,0.00003511792,0.00009406861,0.00009988975,0.00001249344],"category_scores_gemma":[0.00001439326,0.00007260029,0.00004905341,0.00007358677,0.00008741071,0.000004442072,0.00004835327,0.00006426102,0.00001155378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004746263,"about_ca_system_score_gemma":0.00001753984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001772326,"about_ca_topic_score_gemma":0.00009349636,"domain_scores_codex":[0.9993017,0.00005116931,0.0001412586,0.0002135585,0.00008885792,0.0002035111],"domain_scores_gemma":[0.9997131,0.00001875289,0.00003499519,0.0001564522,0.00002294852,0.00005374931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004316588,0.00002790875,0.001321335,0.00001423278,0.00001251772,0.000003351482,0.0001675668,0.00001563193,0.9878312,0.00002017612,0.0002446494,0.01029826],"study_design_scores_gemma":[0.0003559369,0.0001669032,0.09475147,0.00000624128,0.000006568617,0.000003453199,0.0002894952,0.0001727386,0.8937848,0.0003511747,0.009979064,0.0001321698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986455,0.0001533361,0.00002903529,0.0005874983,0.0001416632,0.0001203901,0.00001142332,0.00001596475,0.0002951297],"genre_scores_gemma":[0.9939458,0.0007154499,0.00003013788,0.00007236429,0.00007384422,0.00001205074,0.00002685148,0.000009728058,0.00511377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09404642,"threshold_uncertainty_score":0.2960554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528267622301665,"score_gpt":0.2498555636611653,"score_spread":0.2345728874381487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}