{"id":"W4376604893","doi":"10.1016/j.arr.2023.101955","title":"Mitochondrial dysfunction in aging","year":2023,"lang":"en","type":"review","venue":"Ageing Research Reviews","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":304,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University of Manitoba","funders":"Nutrition Scientific Research Foundation of BYHEALTH; Hebei North University; Fondation Brain Canada; ALS Society of Canada","keywords":"Mitophagy; Mitochondrion; Senescence; Cell biology; Reactive oxygen species; Biology; Ageing; Organelle; Oxidative stress; Biochemistry; Autophagy; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007746602,0.00132565,0.002638126,0.002655006,0.0003613514,0.001719217,0.0007993059,0.001544866,0.006995573],"category_scores_gemma":[0.000917786,0.0003428642,0.000612905,0.002428677,0.0005127902,0.001726418,0.001346117,0.00236949,0.003779074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007046483,"about_ca_system_score_gemma":0.001441682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001080072,"about_ca_topic_score_gemma":0.002629038,"domain_scores_codex":[0.9997858,0.00003991943,0.00003398428,0.00003364792,0.0000822664,0.00002438388],"domain_scores_gemma":[0.9996769,0.0001153332,0.00005906395,0.000009725577,0.0000877963,0.0000511232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001799174,0.00007320426,0.00009732139,0.0224468,0.0001381586,0.0001439291,0.00004693985,0.0002525652,0.001288761,0.002009955,0.0668738,0.9064487],"study_design_scores_gemma":[0.0000830191,0.0001403169,0.0007679151,0.009654322,0.0003456579,0.0007073056,0.00007950127,0.000122871,0.0002476865,0.002913724,0.9849095,0.00002823724],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002979436,0.9989105,0.00005644678,0.0001839132,0.000339414,0.000003462919,0.00001298478,0.000005725402,0.0004576432],"genre_scores_gemma":[0.000247017,0.9984702,0.00008929774,0.0002322834,0.0003820306,0.000005345819,0.00002537446,0.000001083659,0.0005472294],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006995573,"threshold_uncertainty_score":0.02340245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3489611002747354,"score_gpt":0.5229802838760285,"score_spread":0.174019183601293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}