{"id":"W4376605182","doi":"10.1016/j.str.2023.04.009","title":"Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives","year":2023,"lang":"en","type":"article","venue":"Structure","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of British Columbia","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Canada Excellence Research Chairs, Government of Canada; Government of Canada","keywords":"RYR1; Ryanodine receptor; Allosteric regulation; Biophysics; Chemistry; Adenosine triphosphate; Endoplasmic reticulum; Biochemistry; Adenosine; Adenine nucleotide; Nucleotide; Cell biology; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001824729,0.0001878452,0.0001735077,0.0000967039,0.0002064453,0.00029973,0.0004389669,0.0002128427,0.002065404],"category_scores_gemma":[0.0003121718,0.0001199844,0.0001045079,0.00008526296,0.0003496707,0.0002225846,0.0002052099,0.0004234857,0.0002640618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003039484,"about_ca_system_score_gemma":0.0001485606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005157143,"about_ca_topic_score_gemma":0.0007326625,"domain_scores_codex":[0.9999248,0.00001839759,0.000006052389,0.00001658131,0.0000182536,0.00001588287],"domain_scores_gemma":[0.999912,0.00002949314,0.0000238351,0.00001525119,0.000006309616,0.00001312495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004262177,0.00003078308,0.0001483834,0.00004064246,0.000004068126,0.0001472032,0.00005012609,0.0004167951,0.9940655,0.002253635,0.0001070089,0.002309631],"study_design_scores_gemma":[0.00006311278,0.0001550752,0.001717012,0.00001104777,0.000009685751,0.0003160886,0.00005015377,0.003993565,0.9905166,0.0005142087,0.002636295,0.00001709606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932935,0.00101589,0.002049841,0.0003172884,0.00005010221,0.00001183011,0.00007368054,0.00006298685,0.003124814],"genre_scores_gemma":[0.9980425,0.0003886099,0.0006745313,0.00004426759,0.000008567124,0.000004926644,0.00004650863,0.0000127518,0.0007773955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002065404,"threshold_uncertainty_score":0.00690943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008268363245067268,"score_gpt":0.2336000681559139,"score_spread":0.2253317049108466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}