{"id":"W4376613424","doi":"10.1002/tcr.202300072","title":"Spirocyclic Iodonium Ylides for Fluorine‐18 Radiolabeling of Non‐Activated Arenes: From Concept to Clinical Research","year":2023,"lang":"en","type":"review","venue":"The Chemical Record","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Centre for Addiction and Mental Health","funders":"Mitacs; Canada Research Chairs; Azrieli Foundation; Emory University","keywords":"Fluorine; Positron emission tomography; Pet imaging; Chemistry; Radiochemistry; Combinatorial chemistry; Organic chemistry; Nuclear medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004840105,0.0005348542,0.0005253669,0.001498708,0.0001773527,0.0006814402,0.0005276705,0.0006386635,0.002901614],"category_scores_gemma":[0.0003351475,0.000306674,0.0002900295,0.001346852,0.0004275398,0.001151955,0.0004780575,0.001487981,0.002419546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004650581,"about_ca_system_score_gemma":0.0004711095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005214785,"about_ca_topic_score_gemma":0.0009668225,"domain_scores_codex":[0.9998766,0.00001850707,0.00001198994,0.0000240323,0.00005251956,0.00001622264],"domain_scores_gemma":[0.9999107,0.00003997074,0.00001613671,0.000004377783,0.00001890424,0.000009832238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008068891,0.0001133627,0.000155403,0.01056836,0.00003716204,0.0003718278,0.0001509241,0.0005479702,0.01876946,0.01562118,0.0210925,0.9324913],"study_design_scores_gemma":[0.00001002995,0.0001086475,0.0003135779,0.0009769093,0.00002306509,0.0008271698,0.00002999231,0.0001002454,0.004131617,0.001501568,0.9919609,0.00001622982],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006014926,0.9959456,0.0004940294,0.0002100225,0.0002441527,0.000008172552,0.00002088798,0.00001381013,0.002461763],"genre_scores_gemma":[0.002598194,0.9947038,0.0004046015,0.000161037,0.0001552032,0.0000110031,0.00002959824,0.000003591698,0.001932937],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002901614,"threshold_uncertainty_score":0.009706855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6623120313692958,"score_gpt":0.6368707390832428,"score_spread":0.02544129228605307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}