{"id":"W4376614822","doi":"10.3390/ijms24108709","title":"How Three Self-Secreted Biofilm Exopolysaccharides of Pseudomonas aeruginosa, Psl, Pel, and Alginate, Can Each Be Exploited for Antibiotic Adjuvant Effects in Cystic Fibrosis Lung Infection","year":2023,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Pseudomonas aeruginosa; Cystic fibrosis; Biofilm; Antibiotics; Microbiology; Adjuvant; Lung infection; Chronic infection; Lung; Antibiotic resistance; Biology; Tobramycin; Antimicrobial; Bacteria; Medicine; Immunology; Internal medicine; Immune system; Gentamicin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001258721,0.0003739474,0.001448661,0.002220524,0.00007507666,0.0002131486,0.0006164459,0.0001766607,0.000004377289],"category_scores_gemma":[0.002688287,0.0002817706,0.0004671,0.001125325,0.0004155002,0.0003515053,0.0001725333,0.0004362179,7.137159e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003270743,"about_ca_system_score_gemma":0.0007836783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002021558,"about_ca_topic_score_gemma":0.00006761842,"domain_scores_codex":[0.9963417,0.0001999257,0.0009533593,0.0004699358,0.001631867,0.0004032331],"domain_scores_gemma":[0.9964806,0.00123882,0.001120858,0.000181615,0.0007727384,0.0002053663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0008664485,0.001112889,0.01552741,0.09566608,0.005474587,0.003617183,0.0008519976,0.0003523095,0.06380809,0.001626703,0.0004435013,0.8106528],"study_design_scores_gemma":[0.02818052,0.03164995,0.03153267,0.6764261,0.01418049,0.0170391,0.001923573,0.0539121,0.08401792,0.00697935,0.0482013,0.00595696],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09832053,0.8925994,0.005894563,0.0006025622,0.0007971107,0.001618833,0.0001193825,0.00003627487,0.00001130987],"genre_scores_gemma":[0.1362051,0.8504788,0.01287655,0.00003439754,0.0001889038,0.00007188449,0.00005570547,0.00006302907,0.0000256267],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8046958,"threshold_uncertainty_score":0.9999635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03723560165726809,"score_gpt":0.361271407792824,"score_spread":0.3240358061355559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}