{"id":"W4376616796","doi":"10.1097/hep.0000000000000458","title":"Future directions in acute liver failure","year":2023,"lang":"en","type":"review","venue":"Hepatology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Vagelos College of Physicians and Surgeons, Columbia University; Imperial College London; University of Alberta; Institut National de la Santé et de la Recherche Médicale; University of Texas Southwestern Medical Center; University of South Carolina; Virginia Commonwealth University; Medical School, University of Michigan; Université de Montréal; Northwestern University; Medical University of South Carolina; Southwestern Medical Foundation; University of Pennsylvania; University of Pittsburgh; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; University of Southern California","keywords":"Medicine; Hepatic encephalopathy; Cirrhosis; Liver disease; Liver injury; Liver failure; Gastroenterology; Internal medicine; Natural history; Encephalopathy; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.0007720789,0.0006875496,0.002106783,0.0009703033,0.0003564705,0.00002432784,0.0005127855,0.003962605,0.001096643],"category_scores_gemma":[0.00008322034,0.0006531145,0.0006053097,0.001543616,0.0001899808,0.0001198324,0.0002103305,0.004723657,0.005239607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003992947,"about_ca_system_score_gemma":0.0004580006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001668595,"about_ca_topic_score_gemma":0.002901015,"domain_scores_codex":[0.994979,0.00219498,0.0009297011,0.0008474643,0.0001464575,0.0009024426],"domain_scores_gemma":[0.9981936,0.0006764845,0.0004032877,0.0004292054,0.00006427881,0.000233198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003088448,0.0001818588,0.0001961921,0.005043659,0.000750807,0.001148748,0.0003247347,0.000001007584,0.000003357981,0.001440037,0.009297227,0.9815815],"study_design_scores_gemma":[0.0003893696,0.00005236106,0.00001041086,0.0006766102,0.001124272,0.0007981995,0.00003024556,0.0001496902,0.00001073198,0.0002607205,0.995927,0.0005703847],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002102497,0.9871381,0.000008737738,0.0005414326,0.007549082,0.001713231,0.0002965285,0.0005322737,0.002010375],"genre_scores_gemma":[0.00007052997,0.9942063,0.00006273309,0.0004546513,0.001248415,0.001216261,0.0002683087,0.0001253505,0.002347444],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9866298,"threshold_uncertainty_score":0.9998165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2274488840532966,"score_gpt":0.4755329614212113,"score_spread":0.2480840773679147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}