{"id":"W4376618226","doi":"10.1001/jamaneurol.2023.1184","title":"Comparative Effectiveness of Autologous Hematopoietic Stem Cell Transplant vs Fingolimod, Natalizumab, and Ocrelizumab in Highly Active Relapsing-Remitting Multiple Sclerosis","year":2023,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Ottawa Hospital; University of Ottawa","funders":"National Health and Medical Research Council; Multiple Sclerosis Australia; Teva Pharmaceutical Industries; Biogen; Medical Research Council; Sanofi","keywords":"Ocrelizumab; Natalizumab; Multiple sclerosis; Fingolimod; Medicine; Relapsing remitting; Hematopoietic stem cell transplantation; Oncology; Immunology; Internal medicine; Rituximab; Transplantation; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006028149,0.0007193136,0.0011375,0.0006296313,0.000246135,0.0008012506,0.0006114379,0.0009343316,0.003402886],"category_scores_gemma":[0.007743357,0.0002875054,0.002656134,0.0004404599,0.0007758607,0.0009417856,0.0004634159,0.0015886,0.000240731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007948103,"about_ca_system_score_gemma":0.0005744299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004392463,"about_ca_topic_score_gemma":0.0007619914,"domain_scores_codex":[0.9947265,0.004093979,0.0003453809,0.0002734278,0.000358089,0.0002025255],"domain_scores_gemma":[0.9947233,0.002692119,0.001536473,0.0002581814,0.0002057881,0.0005842216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.930168,0.006268366,0.007160092,0.0008870066,0.00612783,0.00005842665,0.00009144047,0.001684418,0.00174718,0.0004159557,0.0004684206,0.04492301],"study_design_scores_gemma":[0.4013064,0.5537099,0.02521595,0.0003031383,0.007926767,0.0002613536,0.0001697142,0.003701604,0.004950307,0.0008274221,0.001580431,0.00004703156],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906479,0.006468601,0.0004251616,0.0002525077,0.0001681731,0.0004227477,0.0003654007,0.0000139481,0.001235608],"genre_scores_gemma":[0.9977567,0.0008740915,0.000337257,0.0001102471,0.0001482992,0.0001932157,0.0002713244,0.000003478887,0.0003054343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006028149,"threshold_uncertainty_score":0.03188026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05018346486246307,"score_gpt":0.2903163344333198,"score_spread":0.2401328695708567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}