{"id":"W4376630331","doi":"10.3390/cells12091332","title":"Novel Therapeutic Target Critical for SARS-CoV-2 Infectivity and Induction of the Cytokine Release Syndrome","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Receptor; Cell biology; Internalization; Cytokine; Infectivity; Neuraminidase; Chemistry; Biology; Enzyme; Virus; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002053967,0.0004892757,0.0006763935,0.0002515957,0.0002055605,0.0004008535,0.0002022108,0.0005502656,0.001951543],"category_scores_gemma":[0.00008138363,0.0001112877,0.0003318539,0.0001118287,0.0002343323,0.000324161,0.000203969,0.001240467,0.0004884702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000319175,"about_ca_system_score_gemma":0.0002951039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001812924,"about_ca_topic_score_gemma":0.0004337873,"domain_scores_codex":[0.9998752,0.00002104801,0.00000772702,0.0000184273,0.00003123316,0.0000463],"domain_scores_gemma":[0.9999558,0.000006422616,0.00001091578,0.00000364743,0.000009275807,0.00001388164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003474366,0.0002734332,0.0001561291,0.0001046193,0.0000116843,0.0003537719,0.00003442894,0.0002107237,0.9896469,0.0008459328,0.0002379315,0.007777028],"study_design_scores_gemma":[0.0004589815,0.005536709,0.002696105,0.00003695453,0.00007128889,0.002704451,0.00006213759,0.001937594,0.9572371,0.0005299845,0.0287092,0.0000194754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.949187,0.02201843,0.01611927,0.001446293,0.0004665171,0.0005649228,0.0005266877,0.0002272614,0.009443558],"genre_scores_gemma":[0.9772873,0.007466774,0.008624408,0.0006031147,0.0001595148,0.0002234175,0.0005929423,0.00002063379,0.005021965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001951543,"threshold_uncertainty_score":0.006528556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07079513826413131,"score_gpt":0.3654183414028717,"score_spread":0.2946232031387404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}