{"id":"W4376630331","doi":"10.3390/cells12091332","title":"Novel Therapeutic Target Critical for SARS-CoV-2 Infectivity and Induction of the Cytokine Release Syndrome","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Receptor; Cell biology; Internalization; Cytokine; Infectivity; Neuraminidase; Chemistry; Biology; Enzyme; Virus; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003723943,0.0001050565,0.0002210608,0.0001114045,0.00008122018,0.00001413189,0.00008233943,0.0001046392,0.000003364629],"category_scores_gemma":[0.000393559,0.00007374981,0.00009440229,0.0004102917,0.0002169243,0.00006183277,0.00007408032,0.0002074274,0.00002305574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004132596,"about_ca_system_score_gemma":0.000124888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007489999,"about_ca_topic_score_gemma":0.000006028497,"domain_scores_codex":[0.9990739,0.00004200766,0.0001588991,0.0002261889,0.0002426627,0.0002564075],"domain_scores_gemma":[0.9991633,0.0003794927,0.00003222643,0.0002851626,0.0001175411,0.00002231773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001132223,0.0001696141,0.004301793,0.0003025634,0.00003450023,0.000009842992,0.0000940731,4.304265e-7,0.9931455,0.0002961876,0.0003808092,0.001151473],"study_design_scores_gemma":[0.001072943,0.0002965694,0.02747914,0.00006017974,0.00005426888,0.00007164999,0.0000382021,0.0008364932,0.9538133,0.001420794,0.01477487,0.00008160333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996696,0.0001004387,0.001073331,0.001014018,0.00023939,0.0005426357,0.00003223632,0.00004910045,0.0002528645],"genre_scores_gemma":[0.9949312,0.000004278766,0.0001079576,0.004770023,0.00007841325,0.00004535013,0.000002016068,0.00002225887,0.00003851175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0393322,"threshold_uncertainty_score":0.300743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07079513826413131,"score_gpt":0.3654183414028717,"score_spread":0.2946232031387404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}