{"id":"W4376630776","doi":"10.1210/endocr/bqad076","title":"Novel Candidate Regulators and Developmental Trajectory of Pituitary Thyrotropes","year":2023,"lang":"en","type":"article","venue":"Endocrinology","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Biotechnology and Biological Sciences Research Council; National Institute of General Medical Sciences; Medical Research Council; National Institutes of Health; Wellcome Trust; Francis Crick Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Thyrotropic cell; Pars tuberalis; Biology; Internal medicine; Gonadotropic cell; Endocrinology; Cell biology; Pituitary gland; Hormone; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003930505,0.0001063447,0.0001372958,0.00006993928,0.00004791162,0.000003573656,0.0001024222,0.0000712689,0.0000138183],"category_scores_gemma":[0.00002252116,0.0001023682,0.00003797829,0.00007642944,0.0001508746,0.000002305617,0.00007749495,0.00005809594,0.000007808847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006950052,"about_ca_system_score_gemma":0.00005054334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001116329,"about_ca_topic_score_gemma":0.0001222286,"domain_scores_codex":[0.9992983,0.00001982196,0.0001545115,0.000227486,0.00005433017,0.0002455564],"domain_scores_gemma":[0.9997767,0.00001192651,0.00003237091,0.0001157791,0.00002053536,0.0000427453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000596629,0.00002824099,0.01561768,0.00001657292,0.0000554157,0.000007651873,0.00008856691,0.0000143878,0.980436,0.0001779793,0.0008292783,0.002668505],"study_design_scores_gemma":[0.001289645,0.0002790585,0.1175294,0.000009745555,0.00001837579,0.0001267854,0.0002519634,0.00003015677,0.8547976,0.00006338763,0.0253671,0.0002367566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982009,0.0005205644,0.0001947234,0.00008063137,0.000191486,0.00007982302,0.00002663003,0.00002525462,0.0006799707],"genre_scores_gemma":[0.9979289,0.0004903605,0.0008867371,0.00008820445,0.00006851716,0.000009023165,0.00007547517,0.0000160932,0.000436753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1256384,"threshold_uncertainty_score":0.4174454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533558827235606,"score_gpt":0.2272145344876688,"score_spread":0.2118789462153128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}