{"id":"W4376630776","doi":"10.1210/endocr/bqad076","title":"Novel Candidate Regulators and Developmental Trajectory of Pituitary Thyrotropes","year":2023,"lang":"en","type":"article","venue":"Endocrinology","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Biotechnology and Biological Sciences Research Council; National Institute of General Medical Sciences; Medical Research Council; National Institutes of Health; Wellcome Trust; Francis Crick Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Thyrotropic cell; Pars tuberalis; Biology; Internal medicine; Gonadotropic cell; Endocrinology; Cell biology; Pituitary gland; Hormone; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101866,0.0001372651,0.0002048353,0.0003154998,0.0001803328,0.0004225321,0.0001593568,0.0001781072,0.00128359],"category_scores_gemma":[0.0001377236,0.0001229769,0.0001819451,0.0002021869,0.0001655775,0.0002257542,0.000165863,0.0002574717,0.000345556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002199324,"about_ca_system_score_gemma":0.000226788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001205231,"about_ca_topic_score_gemma":0.002732431,"domain_scores_codex":[0.9999323,0.000003033231,0.000003916035,0.00003091117,0.00001740288,0.00001241123],"domain_scores_gemma":[0.9998702,0.00002326505,0.00003867365,0.000009487235,0.00002567639,0.00003279959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004799274,0.000002472198,0.003373598,0.00003303165,0.000003600823,0.00007017217,0.00005615524,0.00004534832,0.9939201,0.0001407201,0.00004275815,0.002264094],"study_design_scores_gemma":[0.00001233526,0.0001590192,0.4431149,0.00003276134,0.00005225406,0.001238112,0.0005433472,0.002974955,0.5393691,0.0004647136,0.01200891,0.00002948047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834684,0.002732478,0.009020462,0.0000807867,0.00001670709,0.00002518806,0.002014453,0.0001262823,0.002515131],"genre_scores_gemma":[0.9805058,0.001715073,0.009242531,0.00009335569,0.00001709175,0.00005393442,0.00225628,0.00008379114,0.006032091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00128359,"threshold_uncertainty_score":0.004294038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533558827235606,"score_gpt":0.2272145344876688,"score_spread":0.2118789462153128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}