{"id":"W4376636271","doi":"10.1016/j.jid.2023.04.020","title":"Single-Cell Profiling Reveals Sustained Immune Infiltration, Surveillance, and Tumor Heterogeneity in Infiltrative Basal Cell Carcinoma","year":2023,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"SKiN Health","funders":"Science Fund for Distinguished Young Scholars of Guangxi Province; National Key Research and Development Program of China; Natural Science Foundation of Hunan Province; Natural Science Foundation for Distinguished Young Scholars of Hunan Province; National Natural Science Foundation of China","keywords":"Basal cell carcinoma; Tumor microenvironment; Biology; Chemokine; Proinflammatory cytokine; Pathology; Immune system; Cancer research; Malignancy; Immunology; Inflammation; Medicine; Basal cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009959545,0.00007968973,0.000257272,0.0002975403,0.0001975377,0.0006097049,0.0001168622,0.0002868995,0.0006540867],"category_scores_gemma":[0.0001486148,0.00009873852,0.0001267636,0.0002598119,0.0001342083,0.0002267816,0.0001504054,0.0003530906,0.0002658909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001508891,"about_ca_system_score_gemma":0.0001023053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004516633,"about_ca_topic_score_gemma":0.001045916,"domain_scores_codex":[0.9998822,0.00000841044,0.000006677985,0.00003395458,0.00003748263,0.00003130405],"domain_scores_gemma":[0.9999201,0.00001522693,0.00001638794,0.00001189611,0.0000172394,0.00001914471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001153249,0.00001790837,0.005812925,0.00001905947,0.000009131884,0.00004806246,0.0000513804,0.00007566748,0.9912385,0.00004917465,0.00005703679,0.002505782],"study_design_scores_gemma":[0.00002183889,0.0002966597,0.3658825,0.00001317858,0.00008941272,0.001232316,0.0008633804,0.006703509,0.6205418,0.0003853135,0.00394919,0.00002093259],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971861,0.0005199549,0.001432917,0.00003557937,0.000006160354,0.000009023324,0.0003703006,0.00002670238,0.0004131885],"genre_scores_gemma":[0.9979259,0.0002518866,0.0009178469,0.000041945,0.00000714815,0.00001452529,0.0003288455,0.00001082036,0.0005010151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006540867,"threshold_uncertainty_score":0.002188206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02955788901162275,"score_gpt":0.2709068633268099,"score_spread":0.2413489743151871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}