{"id":"W4376636271","doi":"10.1016/j.jid.2023.04.020","title":"Single-Cell Profiling Reveals Sustained Immune Infiltration, Surveillance, and Tumor Heterogeneity in Infiltrative Basal Cell Carcinoma","year":2023,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"SKiN Health","funders":"Science Fund for Distinguished Young Scholars of Guangxi Province; National Key Research and Development Program of China; Natural Science Foundation of Hunan Province; Natural Science Foundation for Distinguished Young Scholars of Hunan Province; National Natural Science Foundation of China","keywords":"Basal cell carcinoma; Tumor microenvironment; Biology; Chemokine; Proinflammatory cytokine; Pathology; Immune system; Cancer research; Malignancy; Immunology; Inflammation; Medicine; Basal cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006621669,0.0002377175,0.0008901883,0.0005491027,0.00007251203,0.0000249878,0.0001040918,0.0001081901,0.00001583606],"category_scores_gemma":[0.0005305797,0.000204223,0.0001276703,0.0007651058,0.0003535372,0.0001990869,0.000057875,0.000477913,0.000006123078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001272918,"about_ca_system_score_gemma":0.0005374615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003818363,"about_ca_topic_score_gemma":0.00005471261,"domain_scores_codex":[0.9976339,0.0004203927,0.00105634,0.0002423171,0.0002576226,0.0003894253],"domain_scores_gemma":[0.9979371,0.0003347588,0.0007545784,0.0001710125,0.0005380141,0.0002645808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002681383,0.0001266906,0.3332202,0.0004415085,0.00004557379,0.001256039,0.001206842,0.00002576816,0.6620082,0.0001143423,0.001224405,0.00006227403],"study_design_scores_gemma":[0.002993965,0.0004551182,0.1736971,0.00007566272,0.00004422538,0.001113294,0.002060056,0.00009996126,0.8184415,0.0006166424,0.000242932,0.0001596019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952205,0.001175383,0.00004966696,0.002262049,0.0001692278,0.0003791526,0.0000201637,0.0000174918,0.0007063774],"genre_scores_gemma":[0.9970478,0.0001038899,0.001914859,0.0007087982,0.00008998968,0.00001197595,0.00002392812,0.0000260198,0.00007274727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1595231,"threshold_uncertainty_score":0.8327974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02955788901162275,"score_gpt":0.2709068633268099,"score_spread":0.2413489743151871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}