{"id":"W4376637592","doi":"10.1139/cjpp-2022-0454","title":"CD38 deficiency promotes skeletal muscle and brown adipose tissue energy expenditure through activating NAD<sup>+</sup>-Sirt1-PGC1α signaling pathway","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Nanchang University; Natural Science Foundation of Jiangxi Province; National Natural Science Foundation of China","keywords":"Endocrinology; Internal medicine; Brown adipose tissue; NAD+ kinase; CD38; Biology; Adipose tissue; Skeletal muscle; Chemistry; Uncoupling protein; Downregulation and upregulation; Biochemistry; Cell biology; Medicine; Enzyme; Stem cell","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001237622,0.0003795133,0.0002766892,0.0002350287,0.0002386527,0.0002289955,0.0002014032,0.0002143669,0.002823912],"category_scores_gemma":[0.00009484957,0.0001319212,0.0003092761,0.0001489381,0.0003110603,0.0002050757,0.000307291,0.0004902289,0.0003340053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004131708,"about_ca_system_score_gemma":0.0003756851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001740019,"about_ca_topic_score_gemma":0.003039818,"domain_scores_codex":[0.9998752,0.00001465002,0.000009453476,0.0000280007,0.00003306171,0.00003966092],"domain_scores_gemma":[0.9999292,0.00000360581,0.00002276911,0.000005378901,0.00001252996,0.0000265569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009936076,0.00007922605,0.00184459,0.0002579435,0.00002539784,0.0002418943,0.0000434635,0.00006999561,0.9887114,0.000246088,0.0003394694,0.007147012],"study_design_scores_gemma":[0.0003863602,0.001781319,0.09170046,0.0001113875,0.0002147385,0.001568717,0.0003626307,0.002360371,0.8744612,0.0009076238,0.02611638,0.000028854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864663,0.007313002,0.002459384,0.0005220158,0.00009195805,0.00002682088,0.0005692184,0.0001745197,0.00237675],"genre_scores_gemma":[0.9910051,0.002700594,0.001600225,0.0001102697,0.0000216244,0.00003362376,0.0005183413,0.00002554275,0.00398476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002823912,"threshold_uncertainty_score":0.009446979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315442187771131,"score_gpt":0.2569582746869081,"score_spread":0.2438038528091968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}