{"id":"W4376640603","doi":"10.1128/jb.00114-23","title":"An Amino Acid Substitution in Elongation Factor EF-G1A Alters the Antibiotic Susceptibility of Pseudomonas aeruginosa LasR-Null Mutants","year":2023,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Francisco; National Institutes of Health; Queen's University; National Institute of General Medical Sciences; Kansas IDeA Network of Biomedical Research Excellence; Université de Franche-Comté; National Institute of Allergy and Infectious Diseases; Fulbright Association; University of Washington; Robert and Janice McNair Foundation; Center for Undergraduate Research and Scholarship, Bowling Green State University; U.S. Department of Education","keywords":"Biology; Pseudomonas aeruginosa; Mutant; Microbiology; Elongation factor; Antibiotics; Elongation; Amino acid substitution; Biochemistry; Bacteria; Genetics; RNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001629606,0.0007294029,0.0003184917,0.0003683961,0.0001839006,0.000272376,0.0004011407,0.0006408319,0.002448452],"category_scores_gemma":[0.0003404936,0.000176792,0.0003502945,0.000216438,0.0004670593,0.0001589872,0.0002816855,0.0006731982,0.000953698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003078405,"about_ca_system_score_gemma":0.000293667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001458067,"about_ca_topic_score_gemma":0.001292046,"domain_scores_codex":[0.9997926,0.00004736731,0.00002591809,0.00003039074,0.0000618303,0.00004194263],"domain_scores_gemma":[0.9996045,0.0001318124,0.0001011117,0.00004877819,0.00002341042,0.00009033498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008822168,0.00002050278,0.0001135038,0.00001071651,0.000004372814,0.0001028426,0.000006935091,0.00005816385,0.9990005,0.00003714107,0.00002326371,0.000533798],"study_design_scores_gemma":[0.00003006218,0.000242437,0.008284136,0.00001468335,0.00002336427,0.0007358432,0.0000690747,0.001769815,0.9871668,0.00009296675,0.001547431,0.00002336142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953017,0.0003767792,0.002393891,0.0002121381,0.00008454276,0.0000184038,0.0004284292,0.0001501521,0.001033877],"genre_scores_gemma":[0.9969805,0.0001595446,0.001295323,0.00008043987,0.000007938987,0.00001567139,0.0002077957,0.00007424482,0.00117846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002448452,"threshold_uncertainty_score":0.00819087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01613853740927957,"score_gpt":0.2659231122578855,"score_spread":0.2497845748486059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}