{"id":"W4376640918","doi":"10.1002/alz.13119","title":"Plasma and CSF concentrations of N‐terminal tau fragments associate with in vivo neurofibrillary tangle burden","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; HORIZON EUROPE Framework Programme; Olav Thon Stiftelsen; Paulon Säätiö; Orionin Tutkimussäätiö; UK Dementia Research Institute; Vetenskapsrådet; Hjärnfonden; Academy of Finland; EU Joint Programme – Neurodegenerative Disease Research; European Commission; Fondation Brain Canada; Familjen Erling-Perssons Stiftelse; Stiftelsen för Gamla Tjänarinnor; Alzheimer's Association; Consortium canadien en neurodégénérescence associée au vieillissement; Canadian Institutes of Health Research; Weston Brain Institute; Alzheimer's Drug Discovery Foundation","keywords":"Tangle; In vivo; Cerebrospinal fluid; Tau protein; Biomarker; Chemistry; Positron emission tomography; Neurofibrillary tangle; Pathology; Neurodegeneration; Magnetic resonance imaging; Alzheimer's disease; Pittsburgh compound B; Cognitive decline; Neuroscience; Psychology; Medicine; Senile plaques; Biochemistry; Disease; Biology; Dementia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004761177,0.0006067123,0.0003328381,0.0007777531,0.0002727336,0.0006307329,0.0001894022,0.0005046141,0.001175867],"category_scores_gemma":[0.001203243,0.0002200507,0.0002139875,0.0003643616,0.0003179562,0.0002928514,0.0002434449,0.0004017971,0.0003159552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002677477,"about_ca_system_score_gemma":0.0001933411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001292811,"about_ca_topic_score_gemma":0.001524716,"domain_scores_codex":[0.9998036,0.00003270658,0.00001928579,0.00007803791,0.0000454231,0.00002098406],"domain_scores_gemma":[0.9992555,0.000114039,0.0003906169,0.0000637492,0.00009333948,0.00008278691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003138882,0.0003442172,0.8082429,0.0001354557,0.0003999762,0.0006846606,0.0003308998,0.0002863636,0.1700283,0.00006590498,0.0004500956,0.01589239],"study_design_scores_gemma":[0.00003453152,0.000602617,0.9768115,0.00001615778,0.0001085207,0.00245261,0.0001175208,0.0004773848,0.01877205,0.0001425432,0.0004500487,0.0000146007],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977528,0.0006854698,0.0006754725,0.00002382917,0.000008547487,0.0000146475,0.0005100605,0.00002845857,0.0003006434],"genre_scores_gemma":[0.9979493,0.0001897957,0.0009907885,0.00002327161,0.00001137733,0.00002604224,0.0003759354,0.000005652973,0.0004279282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001292811,"threshold_uncertainty_score":0.003933728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02238875425717756,"score_gpt":0.2955162448594245,"score_spread":0.2731274906022469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}