{"id":"W4376641322","doi":"10.1158/2159-8290.c.6649132.v1","title":"Data from Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Medical Research Council; Genentech; Ipsen; Ono Pharmaceutical; Cancer Research UK; Gordon and Rose McAlpine Foundation for Neuroscience Research; Francis Crick Institute; Wellcome Trust; National Institute for Health and Care Research; Melanoma Research Alliance; Invitae; Bristol-Myers Squibb; AstraZeneca; Pfizer; Rosetrees Trust; U.S. Department of Defense","keywords":"Biology; Melanoma; Cancer research; Loss of heterozygosity; Amplicon; Genetics; Gene; Allele; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001629623,0.0003902423,0.0005703698,0.001756723,0.0007531946,0.001516636,0.0004231637,0.0004662788,0.00292838],"category_scores_gemma":[0.004026913,0.0002137811,0.0006961527,0.001650841,0.0004589111,0.0007678838,0.001664821,0.001001731,0.0016239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004226142,"about_ca_system_score_gemma":0.0006048965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001396286,"about_ca_topic_score_gemma":0.005073402,"domain_scores_codex":[0.9989697,0.000239995,0.0000915674,0.000367589,0.0002228076,0.0001083125],"domain_scores_gemma":[0.9977501,0.0006535489,0.0003243552,0.0004400862,0.0006006664,0.0002312046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001160225,0.0001594798,0.5486425,0.002033414,0.001642938,0.001872172,0.001602679,0.002954704,0.2764359,0.002945418,0.02553827,0.1350123],"study_design_scores_gemma":[0.00003270449,0.0002120481,0.8713543,0.0003406755,0.0004650239,0.002723614,0.001043217,0.004438343,0.01648512,0.007062797,0.09577043,0.00007160943],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8628453,0.01345266,0.02752601,0.003646808,0.0002606911,0.0001499518,0.07937284,0.0007138909,0.01203183],"genre_scores_gemma":[0.8253585,0.004636155,0.01842345,0.001659331,0.0002022999,0.000224173,0.1447956,0.0006135013,0.00408702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00292838,"threshold_uncertainty_score":0.009796381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1500584193282261,"score_gpt":0.3023461955995019,"score_spread":0.1522877762712758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}