{"id":"W4376642583","doi":"10.1038/s41467-023-36120-z","title":"Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Sleep & Circadian Network; Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"Janssen Biotech; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Institute of Mental Health; Key Programme; National Defense Science and Engineering Graduate; Instrumentariumin Tiedesäätiö; Sigrid Juséliuksen Säätiö; Suomen Kulttuurirahasto; Academy of Finland; Genentech; National Natural Science Foundation of China; Business Finland; U.S. Department of Health and Human Services; Deutscher Akademischer Austauschdienst; Maze Therapeutics; Yrjö Jahnssonin Säätiö; Jazz Pharmaceuticals; Etelä-Karjalan Rahasto; Jalmari ja Rauha Ahokkaan Säätiö; Pfizer; Biogen; Novartis; Celgene; Stanford Research Computing Center, Stanford University; AbbVie; U.S. Department of Defense; Sanofi; Bristol-Myers Squibb; National Institutes of Health; GlaxoSmithKline","keywords":"Narcolepsy; Immunology; Biology; Autoimmunity; Genome-wide association study; Immune system; Human leukocyte antigen; Genetics; Single-nucleotide polymorphism; Genotype; Gene; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002070233,0.0002921667,0.0002185152,0.000653856,0.0002723306,0.0004468417,0.0001967735,0.0002419875,0.002614734],"category_scores_gemma":[0.0004901124,0.0001378446,0.0004536466,0.0005245939,0.0001510517,0.0001213878,0.0003086286,0.0002233757,0.00021458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001556786,"about_ca_system_score_gemma":0.0001426121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005312246,"about_ca_topic_score_gemma":0.007280056,"domain_scores_codex":[0.9998618,0.0000296747,0.00001280914,0.0000529147,0.00002334184,0.00001948547],"domain_scores_gemma":[0.9997812,0.00004261304,0.0001030686,0.00001887055,0.00001952101,0.00003465413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009442281,0.00003295401,0.9279549,0.00007844566,0.0006903274,0.001184693,0.0003551971,0.0004398919,0.05224311,0.0002928424,0.0004875461,0.01529594],"study_design_scores_gemma":[0.000008865664,0.00003522933,0.9976273,0.00001297839,0.0001253768,0.0005873868,0.00008266077,0.000252524,0.0007235604,0.0001464015,0.0003942491,0.000003465123],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979033,0.0008397019,0.0003037023,0.00009370186,0.000005713731,0.000003045876,0.0002985303,0.00001188613,0.0005403382],"genre_scores_gemma":[0.9986369,0.0002924508,0.0002525632,0.00003402145,0.00001070691,0.000002842402,0.000313436,0.00000714199,0.0004500513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005312246,"threshold_uncertainty_score":0.0105626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0276134810999814,"score_gpt":0.3255270426347348,"score_spread":0.2979135615347534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}