{"id":"W4376642583","doi":"10.1038/s41467-023-36120-z","title":"Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Sleep & Circadian Network; Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"Janssen Biotech; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Institute of Mental Health; Key Programme; National Defense Science and Engineering Graduate; Instrumentariumin Tiedesäätiö; Sigrid Juséliuksen Säätiö; Suomen Kulttuurirahasto; Academy of Finland; Genentech; National Natural Science Foundation of China; Business Finland; U.S. Department of Health and Human Services; Deutscher Akademischer Austauschdienst; Maze Therapeutics; Yrjö Jahnssonin Säätiö; Jazz Pharmaceuticals; Etelä-Karjalan Rahasto; Jalmari ja Rauha Ahokkaan Säätiö; Pfizer; Biogen; Novartis; Celgene; Stanford Research Computing Center, Stanford University; AbbVie; U.S. Department of Defense; Sanofi; Bristol-Myers Squibb; National Institutes of Health; GlaxoSmithKline","keywords":"Narcolepsy; Immunology; Biology; Autoimmunity; Genome-wide association study; Immune system; Human leukocyte antigen; Genetics; Single-nucleotide polymorphism; Genotype; Gene; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007611662,0.0001313389,0.0002177711,0.0005215447,0.0004265646,0.00003801014,0.001175776,0.0002553049,0.00002042706],"category_scores_gemma":[0.001893023,0.000128826,0.000061984,0.00227128,0.0004501212,0.0001371355,0.0007953467,0.001928687,0.00003821563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005406242,"about_ca_system_score_gemma":0.00008879178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003737799,"about_ca_topic_score_gemma":0.0007507046,"domain_scores_codex":[0.9980222,0.0008190592,0.0003051457,0.0002530274,0.0003056726,0.0002948678],"domain_scores_gemma":[0.996411,0.001701156,0.000133645,0.001573538,0.0001009748,0.00007969471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002254585,0.002974897,0.3112042,0.0001590887,0.00005278133,0.00002378358,0.01089806,0.0007635474,0.5643042,0.02100434,0.002438603,0.08595108],"study_design_scores_gemma":[0.006053193,0.0004547033,0.5296777,0.0001375042,0.00007840454,0.00002994449,0.004368971,0.05523208,0.300619,0.01518481,0.08715464,0.001009093],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866325,0.001914078,0.000007929394,0.0009786281,0.00007180704,0.0004647399,0.00008521477,0.0001600532,0.009685071],"genre_scores_gemma":[0.9959707,0.0034118,0.0001468851,0.0001016944,0.00001167244,0.00009705818,0.00002573453,0.00002074554,0.0002137524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2636852,"threshold_uncertainty_score":0.8379293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0276134810999814,"score_gpt":0.3255270426347348,"score_spread":0.2979135615347534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}