{"id":"W4376853964","doi":"10.1039/d3qo00475a","title":"Asymmetric addition of hydrazones as alkyl carbanion equivalents with aryl imines in water","year":2023,"lang":"en","type":"article","venue":"Organic Chemistry Frontiers","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre in Green Chemistry and Catalysis","funders":"National Key Research and Development Program of China; Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Carbanion; Chemistry; Umpolung; Alkyl; Aryl; Equivalent; Medicinal chemistry; Catalysis; Organic chemistry; Nucleophile","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001519731,0.0002453167,0.0003442502,0.0001910844,0.0000922426,0.00003655646,0.0002972493,0.0002012522,0.003048439],"category_scores_gemma":[0.00008417165,0.0002052438,0.000106156,0.001918218,0.00007655569,0.0001307226,0.00009343122,0.0001784145,0.0001207996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001997858,"about_ca_system_score_gemma":0.00006680475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006842631,"about_ca_topic_score_gemma":0.000004445756,"domain_scores_codex":[0.9982669,0.000006993274,0.0003922766,0.0004300722,0.0004998131,0.0004039878],"domain_scores_gemma":[0.9992052,0.00002956924,0.0001500277,0.0004068739,0.00008855852,0.0001198154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008973212,0.0001561899,0.008331385,0.0004912516,0.0002485647,0.00007391269,0.0002756994,0.00005298148,0.977002,0.000002257796,0.006352288,0.006923768],"study_design_scores_gemma":[0.0009812997,0.00001220424,0.0002856655,0.00006902041,0.00008147909,0.00001787485,0.001331791,0.0004286836,0.9929847,0.00005732545,0.003475047,0.0002748842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827308,0.0002961585,0.00009291009,0.0001768116,0.00007764264,0.0000602441,0.00003954316,0.0001514167,0.01637444],"genre_scores_gemma":[0.9876939,0.0001623133,0.00006695485,0.00001433623,0.00007826003,0.00002567291,0.001242395,0.00005149246,0.01066469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01598276,"threshold_uncertainty_score":0.9978629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00507047444972544,"score_gpt":0.1986889103152772,"score_spread":0.1936184358655517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}