{"id":"W4376867977","doi":"10.1089/nat.2022.0062","title":"Sequence-Controlled Spherical Nucleic Acids: Gene Silencing, Encapsulation, and Cellular Uptake","year":2023,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Gene silencing; Nucleic acid; Oligonucleotide; RNA interference; Polymer; DNA; Conjugated system; Biophysics; Chemistry; Gene expression; Gene; RNA; Cell biology; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000301949,0.0002865658,0.0003490607,0.00007551721,0.0002085957,0.00005802124,0.0002071298,0.0002942939,0.00001334007],"category_scores_gemma":[0.0000389893,0.0002439889,0.0001725126,0.0003436499,0.000204922,0.000009327364,0.0001200361,0.0001512277,0.00002599074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002584626,"about_ca_system_score_gemma":0.00004546284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004906316,"about_ca_topic_score_gemma":0.000004263988,"domain_scores_codex":[0.9983817,0.00008686671,0.0003762901,0.0005251808,0.00023709,0.0003929147],"domain_scores_gemma":[0.9991103,0.00001859057,0.0001529524,0.0004871379,0.0001250803,0.0001059584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001069034,0.00003248317,0.0004647381,0.000006764119,0.0001536108,0.000009592604,0.00007998239,0.00001493749,0.9889671,0.00005553814,0.0001886669,0.009919745],"study_design_scores_gemma":[0.001222009,0.0002493121,0.0008251739,0.00001285881,0.0001402268,0.00002056767,0.0001699026,0.00336107,0.9780076,0.0007693773,0.01484248,0.0003794655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942474,0.000871704,0.003602027,0.0003409424,0.0001075308,0.0002507034,0.00001903396,0.0002421569,0.0003185275],"genre_scores_gemma":[0.9892258,0.00139166,0.007604541,0.0008295969,0.0002610149,0.00001360875,0.000130056,0.0000556034,0.0004880932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01465381,"threshold_uncertainty_score":0.9949578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02294970750070985,"score_gpt":0.2758681371762867,"score_spread":0.2529184296755768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}