{"id":"W4376867977","doi":"10.1089/nat.2022.0062","title":"Sequence-Controlled Spherical Nucleic Acids: Gene Silencing, Encapsulation, and Cellular Uptake","year":2023,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Gene silencing; Nucleic acid; Oligonucleotide; RNA interference; Polymer; DNA; Conjugated system; Biophysics; Chemistry; Gene expression; Gene; RNA; Cell biology; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001964078,0.0003151931,0.0001579122,0.0001208474,0.000112573,0.0002901072,0.0001457494,0.0002512388,0.0003007032],"category_scores_gemma":[0.0003037216,0.0001508235,0.0001130268,0.0001318631,0.0003111728,0.0002551874,0.0001639664,0.0002070965,0.00019026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003713879,"about_ca_system_score_gemma":0.0003257851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005926913,"about_ca_topic_score_gemma":0.001221747,"domain_scores_codex":[0.9998187,0.00003387435,0.0000122065,0.00004244923,0.00007467428,0.00001804113],"domain_scores_gemma":[0.9998918,0.00002582271,0.00004404823,0.000008244874,0.00001571775,0.0000143533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001420978,0.000005793063,0.00004643239,0.000020268,0.000001657497,0.00000658103,0.000007688436,0.0002013873,0.9980574,0.0001733759,0.000009589342,0.001455694],"study_design_scores_gemma":[0.000002304683,0.00004826527,0.0001988767,9.587194e-7,0.000002448627,0.00002601036,0.000002945841,0.0009778109,0.9981694,0.00002930615,0.0005394837,0.000002114464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667808,0.002273104,0.0278696,0.0001341978,0.00002021275,0.00007962568,0.00008668711,0.0001322136,0.002623696],"genre_scores_gemma":[0.9853499,0.00127767,0.01131028,0.0000417911,0.000006407107,0.00004890528,0.00008724962,0.00002881729,0.001848837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005926913,"threshold_uncertainty_score":0.002694547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02294970750070985,"score_gpt":0.2758681371762867,"score_spread":0.2529184296755768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}