{"id":"W4376871489","doi":"10.1001/jamanetworkopen.2023.13734","title":"Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease","year":2023,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University of Toronto; University Health Network","funders":"Vogel Stiftung; Medical Research Council; Hersenstichting; Demensfonden; Grifols; Sunovion; H. Lundbeck A/S; Norges Forskningsråd; Eisai; Servier; Biogen; Pfizer; Alzheimer Nederland; ZonMw; Karolinska Institutet; Eli Lilly and Company; Lundbeckfonden; Ministero della Salute; Alzheimer's Association; FONDATION ALZHEIMER; Instituto de Salud Carlos III; National Research Foundation; Amgen; Novo Nordisk; Bundesministerium für Bildung und Forschung; European Commission","keywords":"Mendelian randomization; Medicine; Dementia; Odds ratio; Disease; Alzheimer's disease; Biobank; Case-control study; Gerontology; Internal medicine; Bioinformatics; Genetics; Genotype; Biology; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007465151,0.0001604748,0.0002528091,0.00003048068,0.0003694703,0.0001094157,0.0003282142,0.0001989243,0.00002651531],"category_scores_gemma":[0.0004155831,0.0001468877,0.00007328465,0.000231157,0.00004777774,0.000007831238,0.0005624717,0.0001192685,0.00005149659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001275518,"about_ca_system_score_gemma":0.000070628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006654178,"about_ca_topic_score_gemma":0.00004850243,"domain_scores_codex":[0.9984809,0.0003083521,0.0002791247,0.000402369,0.0000936387,0.0004355779],"domain_scores_gemma":[0.9990399,0.0001620648,0.0001963431,0.0003379214,0.00005756461,0.000206231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000009218435,0.000009566283,0.9337001,0.000001054824,0.0001957171,8.397182e-7,0.00002590077,0.01398107,0.00002418329,0.0000339402,0.05080605,0.001212392],"study_design_scores_gemma":[0.0003153602,0.00004791505,0.9780322,0.000005122515,0.0001495564,1.987699e-7,0.00002994288,0.002093656,0.00001769965,0.001802612,0.01732348,0.0001822488],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996232,0.0008691968,0.0004006227,0.0007091805,0.0001340882,0.0003841809,0.0003310924,0.00002649603,0.0009131313],"genre_scores_gemma":[0.9948065,0.000991776,0.001339706,0.0001928024,0.0006754065,0.00005720976,0.001107799,0.0000286543,0.0008001362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04433213,"threshold_uncertainty_score":0.5989907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03990388866371153,"score_gpt":0.3030780972593277,"score_spread":0.2631742085956162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}