{"id":"W4376871489","doi":"10.1001/jamanetworkopen.2023.13734","title":"Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease","year":2023,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University of Toronto; University Health Network","funders":"Vogel Stiftung; Medical Research Council; Hersenstichting; Demensfonden; Grifols; Sunovion; H. Lundbeck A/S; Norges Forskningsråd; Eisai; Servier; Biogen; Pfizer; Alzheimer Nederland; ZonMw; Karolinska Institutet; Eli Lilly and Company; Lundbeckfonden; Ministero della Salute; Alzheimer's Association; FONDATION ALZHEIMER; Instituto de Salud Carlos III; National Research Foundation; Amgen; Novo Nordisk; Bundesministerium für Bildung und Forschung; European Commission","keywords":"Mendelian randomization; Medicine; Dementia; Odds ratio; Disease; Alzheimer's disease; Biobank; Case-control study; Gerontology; Internal medicine; Bioinformatics; Genetics; Genotype; Biology; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001134787,0.0005372976,0.0004334738,0.0009141063,0.0003397621,0.0005695039,0.0004628354,0.0005608227,0.003071799],"category_scores_gemma":[0.004343922,0.0001940832,0.0005768085,0.001495486,0.0005157455,0.0002462012,0.0003705575,0.0004300159,0.0002194619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003601772,"about_ca_system_score_gemma":0.0005623155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004974583,"about_ca_topic_score_gemma":0.00523229,"domain_scores_codex":[0.9988061,0.0004175476,0.0001152614,0.0003056078,0.000257841,0.00009757932],"domain_scores_gemma":[0.9984358,0.0006275386,0.0006178872,0.0001332502,0.0001092021,0.00007644205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007871792,0.00007317174,0.9804208,0.0001454893,0.001624296,0.0003199151,0.00008467696,0.0006052363,0.001972665,0.0006575475,0.000539127,0.01276987],"study_design_scores_gemma":[0.00007679257,0.000149127,0.9931731,0.00006606348,0.0008685493,0.0006835612,0.00004743359,0.0009057822,0.00065068,0.001736464,0.00162703,0.00001546733],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814945,0.006705586,0.003605022,0.0007927588,0.00008490707,0.0001007627,0.004401552,0.00006851138,0.00274644],"genre_scores_gemma":[0.9938679,0.00144437,0.002738635,0.00009827845,0.00007293008,0.00003969513,0.001140764,0.000009535458,0.0005878105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004974583,"threshold_uncertainty_score":0.01027614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03990388866371153,"score_gpt":0.3030780972593277,"score_spread":0.2631742085956162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}