{"id":"W4376872045","doi":"10.2147/jir.s401566","title":"FLI1 Regulates Histamine Decarboxylase Expression to Control Inflammation Signaling and Leukemia Progression","year":2023,"lang":"en","type":"article","venue":"Journal of Inflammation Research","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Guizhou Medical University; National Natural Science Foundation of China; National Science Foundation","keywords":"Histidine decarboxylase; Cancer research; Histamine; Allergic inflammation; Jurkat cells; Biology; Chromatin immunoprecipitation; Inflammation; Gene knockdown; Molecular biology; Chemistry; Promoter; Immunology; Gene expression; Apoptosis; T cell; Gene; Immune system; Biochemistry; Enzyme; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001709148,0.0005131353,0.0002480444,0.0003037526,0.0002710486,0.0004384274,0.0002632958,0.0003570545,0.002651873],"category_scores_gemma":[0.0001072594,0.0001238182,0.000368302,0.0002100248,0.000282061,0.0002451024,0.0002814936,0.0008230241,0.0005222514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009020241,"about_ca_system_score_gemma":0.0003600588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006665657,"about_ca_topic_score_gemma":0.001138132,"domain_scores_codex":[0.9998214,0.00001527837,0.000009231313,0.00005030323,0.00002829721,0.00007561455],"domain_scores_gemma":[0.9998988,0.000008011215,0.00004297304,0.00000658312,0.00001210973,0.00003140789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004309413,0.0000547691,0.001244565,0.0001564658,0.00001320049,0.00007365681,0.00003388761,0.0001564992,0.9911089,0.0003126203,0.000422825,0.005991758],"study_design_scores_gemma":[0.00008742257,0.0005097488,0.02294431,0.0000434064,0.0001044773,0.0004083337,0.0001023267,0.002646073,0.9571506,0.0002481201,0.01573806,0.00001698003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9556651,0.0257536,0.008602653,0.00108233,0.000218772,0.0001139301,0.00196773,0.0005865118,0.00600951],"genre_scores_gemma":[0.9912713,0.002321057,0.00151969,0.0002279996,0.00003359539,0.00004212926,0.0009046817,0.00002458911,0.003655039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002651873,"threshold_uncertainty_score":0.008871377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02437097516143747,"score_gpt":0.3561575049250748,"score_spread":0.3317865297636373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}