{"id":"W4376872231","doi":"10.4049/jimmunol.2200720","title":"C3/CD11b-Mediated <i>Leishmania major</i> Internalization by Neutrophils Induces Intraphagosomal NOX2-Mediated Respiratory Burst but Fails to Eliminate Parasites and Induces a State of Stalled Apoptosis","year":2023,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Internalization; Respiratory burst; Leishmania; Cell biology; Biology; Immunology; Microbiology; Chemistry; Cell; Biochemistry; Computer science; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001874112,0.0003234642,0.0002640391,0.00009045973,0.000127167,0.0003365214,0.0001943734,0.0003972385,0.0008867567],"category_scores_gemma":[0.0001320346,0.0001489816,0.000237474,0.00007864385,0.0001748007,0.000187026,0.0001781411,0.000765029,0.0003662678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003885551,"about_ca_system_score_gemma":0.0002578249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001113479,"about_ca_topic_score_gemma":0.00136646,"domain_scores_codex":[0.9997224,0.00004391805,0.0000273897,0.00004411841,0.00006152969,0.0001005873],"domain_scores_gemma":[0.9998921,0.0000129147,0.00003284871,0.00001692838,0.00001682882,0.00002829322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009955406,0.00002984415,0.0001637555,0.00002117904,0.000003669337,0.00003554092,0.000008052854,0.00001829898,0.9991933,0.00003746592,0.00003346996,0.0003559145],"study_design_scores_gemma":[0.00004192183,0.0005454245,0.009673536,0.0000135465,0.00001574114,0.0006051677,0.00003718098,0.001563191,0.9859656,0.00003605791,0.001496709,0.000005902825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996793,0.0005883718,0.001492611,0.00009097696,0.00001426882,0.00002895617,0.0001499627,0.00004710433,0.0007947894],"genre_scores_gemma":[0.9967222,0.0003000906,0.001085198,0.0001019004,0.00000599682,0.00003812903,0.0005107016,0.00001210816,0.001223831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001113479,"threshold_uncertainty_score":0.002966523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02225861374569088,"score_gpt":0.2894516849526225,"score_spread":0.2671930712069316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}