{"id":"W4376872853","doi":"10.4049/jimmunol.2300122","title":"Spi-C and PU.1 Counterregulate <i>Rag1</i> and <i>Ig</i>κ Transcription to Effect Vκ-Jκ Recombination in Small Pre-B Cells","year":2023,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Recombination-activating gene; Transcription (linguistics); Molecular biology; Transcription factor; Chromatin immunoprecipitation; Chromatin; Biology; V(D)J recombination; Gene rearrangement; Gene; Gene expression; Cell biology; Recombination; Promoter; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002182196,0.0005636952,0.0003256667,0.0003250086,0.0001559034,0.0004180845,0.0003134873,0.0003199567,0.001324472],"category_scores_gemma":[0.0001835783,0.0002183913,0.000378572,0.0001233503,0.0005135199,0.0002462479,0.0002550259,0.001105267,0.0002856957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000328888,"about_ca_system_score_gemma":0.0002686669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003512109,"about_ca_topic_score_gemma":0.0003736787,"domain_scores_codex":[0.9996477,0.00005185173,0.00002966436,0.00007550083,0.00009551447,0.00009965027],"domain_scores_gemma":[0.999612,0.00008241699,0.0001259709,0.00004726955,0.00002721862,0.0001051817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007783763,0.00002987937,0.00005173664,0.000021119,0.000002424132,0.00001373322,0.00000625581,0.00003912126,0.9993122,0.00005944025,0.00001238839,0.0003739543],"study_design_scores_gemma":[0.00001315033,0.0003136988,0.001233668,0.000002715416,0.000007991175,0.00005665438,0.000007393886,0.0005531726,0.9972271,0.0000209665,0.0005610266,0.00000241362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946562,0.0009447461,0.003000183,0.00009519501,0.00003179688,0.00003758644,0.0002616853,0.0001699621,0.0008026073],"genre_scores_gemma":[0.9955761,0.0003623416,0.001668756,0.00006551201,0.00001892689,0.00007341435,0.0003917322,0.00003415657,0.001809147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001324472,"threshold_uncertainty_score":0.00443083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008775469639346088,"score_gpt":0.2144163472279226,"score_spread":0.2056408775885765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}