{"id":"W4376875130","doi":"10.1016/j.xops.2023.100332","title":"A New Preclinical Model of Retinitis Pigmentosa Due to Pde6g Deficiency","year":2023,"lang":"en","type":"article","venue":"Ophthalmology Science","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alcon Research Institute; National Eye Institute; Daimler und Benz Stiftung; National Institute on Aging; Research to Prevent Blindness; Deutsche Forschungsgemeinschaft; National Cancer Institute; National Institutes of Health; Foundation Fighting Blindness","keywords":"Retinitis pigmentosa; Retinal pigment epithelium; Retinal; Retinal degeneration; Biology; Photoreceptor cell; Outer nuclear layer; Retina; Pathology; Retinal regeneration; Electroretinography; Anatomy; Cell biology; Medicine; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008419059,0.002320596,0.00103036,0.001971885,0.000895082,0.0008345832,0.001349121,0.001789976,0.007394228],"category_scores_gemma":[0.0003350044,0.0006434062,0.001094796,0.0005246176,0.0009199554,0.0009706393,0.0006539501,0.003358913,0.00204286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009834714,"about_ca_system_score_gemma":0.0006756036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00140254,"about_ca_topic_score_gemma":0.0023886,"domain_scores_codex":[0.9989914,0.00008681091,0.0001143182,0.0003289929,0.0003092101,0.0001693181],"domain_scores_gemma":[0.9989538,0.00009128771,0.0003534044,0.0001698457,0.0001025017,0.000329086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001559917,0.00147198,0.0005123346,0.0001938166,0.00003736915,0.0004028796,0.00009347933,0.0002004864,0.9902582,0.0007967456,0.0006057004,0.003867108],"study_design_scores_gemma":[0.001194879,0.0228418,0.00858708,0.0002198196,0.0002626797,0.003063708,0.0001869036,0.002948074,0.9329798,0.0007880207,0.02685256,0.00007470032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.941511,0.00749922,0.0216214,0.001801031,0.001616476,0.002718248,0.008702626,0.002108717,0.01242122],"genre_scores_gemma":[0.8885881,0.005928333,0.03067876,0.001011375,0.0002551482,0.004717828,0.006761455,0.0003952126,0.06166376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007394228,"threshold_uncertainty_score":0.02473617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04433158678263343,"score_gpt":0.3398727644076656,"score_spread":0.2955411776250322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}