{"id":"W4376875130","doi":"10.1016/j.xops.2023.100332","title":"A New Preclinical Model of Retinitis Pigmentosa Due to Pde6g Deficiency","year":2023,"lang":"en","type":"article","venue":"Ophthalmology Science","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alcon Research Institute; National Eye Institute; Daimler und Benz Stiftung; National Institute on Aging; Research to Prevent Blindness; Deutsche Forschungsgemeinschaft; National Cancer Institute; National Institutes of Health; Foundation Fighting Blindness","keywords":"Retinitis pigmentosa; Retinal pigment epithelium; Retinal; Retinal degeneration; Biology; Photoreceptor cell; Outer nuclear layer; Retina; Pathology; Retinal regeneration; Electroretinography; Anatomy; Cell biology; Medicine; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005960529,0.0001071549,0.0001433359,0.0001376233,0.0001049536,0.00001418051,0.0005557505,0.0000951512,0.00005180013],"category_scores_gemma":[0.0005760539,0.0001020716,0.00005246136,0.0007523443,0.0003540714,0.000006843704,0.0003694537,0.0000558116,0.00009576932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008509746,"about_ca_system_score_gemma":0.0005795077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001562179,"about_ca_topic_score_gemma":0.000001669148,"domain_scores_codex":[0.9986014,0.00002648896,0.000241285,0.0004962867,0.0002461562,0.0003883537],"domain_scores_gemma":[0.9993346,0.00002400168,0.0000635277,0.0003122053,0.00008821877,0.0001774875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001407586,0.00007175518,0.03731349,0.00001701049,0.000008685528,0.00005268008,0.0002768693,0.001551878,0.9489751,0.0012078,0.006610335,0.003773677],"study_design_scores_gemma":[0.002022588,0.004092586,0.4636838,0.00009032025,0.00003868887,0.001351642,0.0005948222,0.007332334,0.5007665,0.01527739,0.003214938,0.001534494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753411,0.00004930606,0.002050416,0.000500563,0.0001838735,0.0001449495,0.000005403178,0.00001371245,0.02171068],"genre_scores_gemma":[0.9877952,0.00002108143,0.008246957,0.0001155807,0.00002525706,0.00001220882,0.00001254423,0.000007807803,0.003763389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4482086,"threshold_uncertainty_score":0.4162358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04433158678263343,"score_gpt":0.3398727644076656,"score_spread":0.2955411776250322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}