{"id":"W4376878477","doi":"10.1038/s41586-023-06191-5","title":"Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Pyroptosis; Antibody; Programmed cell death; Inflammation; Apoptosis; Chemistry; Molecular biology; Immunology; Medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000964145,0.0001597712,0.0001260027,0.00006290337,0.0001145658,0.00002633681,0.0001441169,0.0008609609,0.00001828945],"category_scores_gemma":[0.00007148644,0.0001280454,0.00004618206,0.0002527049,0.00005201592,0.000005921962,0.00006992345,0.000683771,0.00005512474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004013973,"about_ca_system_score_gemma":0.00004086496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003852554,"about_ca_topic_score_gemma":0.000021467,"domain_scores_codex":[0.9991818,0.00002318606,0.0001079432,0.0002690575,0.0001405258,0.0002774769],"domain_scores_gemma":[0.999596,0.000007216034,0.0000488401,0.0002254373,0.00008827058,0.00003425037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009603469,0.00001317478,0.001322609,0.00003871394,0.00005006939,0.00001891027,0.0001207034,0.00002472929,0.9711218,0.00007934606,0.02330538,0.003808547],"study_design_scores_gemma":[0.0002999223,0.0001759035,0.00213448,0.00003434118,0.0000116871,0.00001135758,0.0002632393,0.000005075163,0.817618,0.00002001805,0.1792297,0.0001963171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909074,0.002229855,0.000007787422,0.0008084234,0.0001735329,0.0001302203,0.00002322869,0.00006446629,0.005655081],"genre_scores_gemma":[0.9937044,0.0004409646,0.0001352261,0.0009804595,0.0002525723,0.000009758111,0.0004810971,0.00003240251,0.003963059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1559244,"threshold_uncertainty_score":0.6640518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004675264341645938,"score_gpt":0.2527608888673546,"score_spread":0.2480856245257087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}