{"id":"W4376954750","doi":"10.1016/j.acthis.2023.152045","title":"KCCs, NKCCs, and NCC: Potential targets for cardiovascular therapeutics? A comprehensive review of cell and region specific expression and function","year":2023,"lang":"en","type":"review","venue":"Acta Histochemica","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"The Scarborough Hospital; Krembil Foundation; University of Toronto","funders":"","keywords":"Internal medicine; Homeostasis; Endocrinology; Depolarization; Cardiomyopathy; Biology; Heart failure; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001713242,0.0003450119,0.001070898,0.00005718969,0.00008462641,0.00001596501,0.0001120083,0.0003794394,0.000004971243],"category_scores_gemma":[0.00001768403,0.0002985202,0.0005198178,0.00005983262,0.00008967453,0.000004998376,0.0001518031,0.0001366149,5.534731e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001886524,"about_ca_system_score_gemma":0.00004287797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002233282,"about_ca_topic_score_gemma":6.594189e-8,"domain_scores_codex":[0.9985175,0.00008438456,0.000425023,0.00064069,0.0001419228,0.0001904699],"domain_scores_gemma":[0.999032,0.0000350071,0.0003273519,0.0004060534,0.0001235107,0.00007612008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006214422,0.00002433327,1.586111e-7,0.1026702,0.000590602,0.00000324251,0.00001817924,1.071985e-7,0.6875063,0.000007540329,0.006708665,0.2024085],"study_design_scores_gemma":[0.0003116743,0.0001726616,1.165014e-7,0.01140128,0.001153701,0.00003597329,0.00001667043,0.00000203805,0.01817619,0.00003440536,0.9683996,0.0002957144],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000159809,0.9966288,0.001869864,0.00001016177,0.000188168,0.001067876,0.00004381812,0.00001155563,0.00001993289],"genre_scores_gemma":[0.000185746,0.9977343,0.0009781851,0.00004658203,0.0002197297,0.0001123921,0.0005418062,0.00007040143,0.0001108445],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9616909,"threshold_uncertainty_score":0.9999467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04124284094410354,"score_gpt":0.2710288052977478,"score_spread":0.2297859643536442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}