{"id":"W4376956870","doi":"10.3389/fimmu.2023.1166574","title":"Dysregulated early transcriptional signatures linked to mast cell and interferon responses are implicated in COVID-19 severity","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science Foundation Ireland; Wellcome Trust; Canadian Institute for Theoretical Astrophysics","keywords":"Coronavirus disease 2019 (COVID-19); Mast cell; Interferon; 2019-20 coronavirus outbreak; Immunology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Medicine; Virology; Disease; Infectious disease (medical specialty); Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002677142,0.0002591953,0.0003449135,0.0004370752,0.000153076,0.0003152902,0.0001104196,0.0002530958,0.001724039],"category_scores_gemma":[0.0002716556,0.000117282,0.0002234519,0.0002862238,0.0002286621,0.0001329615,0.0002088831,0.0003502619,0.000273464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000183656,"about_ca_system_score_gemma":0.0001157605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002501596,"about_ca_topic_score_gemma":0.0003463837,"domain_scores_codex":[0.9998097,0.00002625899,0.00001879418,0.00006398781,0.0000409356,0.00004043272],"domain_scores_gemma":[0.9996535,0.00003748299,0.0001893437,0.00002031378,0.0000395402,0.00005983211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002048924,0.00009521646,0.3148615,0.0001351349,0.00006598162,0.0004353097,0.0001731391,0.0001222278,0.6758178,0.00006527526,0.0001610179,0.006018462],"study_design_scores_gemma":[0.000008720777,0.0003471129,0.97741,0.00001021524,0.00003184052,0.0005917403,0.0001123637,0.0002240832,0.02080008,0.00006734773,0.0003915777,0.00000486633],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984138,0.000458535,0.0003301176,0.00002021826,0.000006164551,0.00001610817,0.0004455913,0.00001018837,0.0002993032],"genre_scores_gemma":[0.9978918,0.0002769316,0.0005814456,0.00002984385,0.00001262098,0.00002650461,0.0007519379,0.000005473998,0.0004233676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001724039,"threshold_uncertainty_score":0.005767465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03762893279030111,"score_gpt":0.3629386067857952,"score_spread":0.3253096739954941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}