{"id":"W4377014075","doi":"10.1093/jnci/djad095","title":"Feasibility and value of genomic profiling in cancer of unknown primary: real-world evidence from prospective profiling study","year":2023,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Cancer Diagnosis and Treatment","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"National Cancer Institute; University of Texas MD Anderson Cancer Center; National Institutes of Health; Jackson Laboratory","keywords":"Profiling (computer programming); Medicine; Clinical endpoint; Prospective cohort study; Oncology; Internal medicine; Clinical trial; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008041964,0.0001284187,0.0004839216,0.0002366489,0.00005455426,0.000009337873,0.0001477445,0.00003060653,0.00001599889],"category_scores_gemma":[0.0002558134,0.00008619415,0.0001186282,0.0006082892,0.0001255809,0.0002182429,0.00009076669,0.0002424351,3.643871e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002343556,"about_ca_system_score_gemma":0.002164698,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006729359,"about_ca_topic_score_gemma":0.007659186,"domain_scores_codex":[0.9980851,0.00007030572,0.0006919021,0.000217419,0.0008076302,0.0001276902],"domain_scores_gemma":[0.9982621,0.000199366,0.0006483386,0.0001328271,0.0007011081,0.00005626516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008231362,0.0003955325,0.9813309,0.0001480337,0.0003002313,0.00001009564,0.0007579334,0.006103208,0.009143651,0.0002503285,0.00006646628,0.0006705317],"study_design_scores_gemma":[0.002730805,0.0001882563,0.9759536,0.001344231,0.0002422975,0.000004335541,0.00008882913,0.0002243447,0.01844683,0.0006719768,0.00003710203,0.00006732138],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941605,0.002901781,0.000002215844,0.0008850993,0.000634905,0.001155022,0.0001157774,0.000005706247,0.0001389481],"genre_scores_gemma":[0.9965333,0.002442185,0.00043583,0.00006303921,0.0003545026,0.00009948928,0.000003170662,0.00001073113,0.00005776899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009303183,"threshold_uncertainty_score":0.9998849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1342148052657563,"score_gpt":0.4158546229617893,"score_spread":0.281639817696033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}