{"id":"W4377014075","doi":"10.1093/jnci/djad095","title":"Feasibility and value of genomic profiling in cancer of unknown primary: real-world evidence from prospective profiling study","year":2023,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Cancer Diagnosis and Treatment","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"National Cancer Institute; University of Texas MD Anderson Cancer Center; National Institutes of Health; Jackson Laboratory","keywords":"Profiling (computer programming); Medicine; Clinical endpoint; Prospective cohort study; Oncology; Internal medicine; Clinical trial; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04501821,0.0006289737,0.001237838,0.0003735302,0.000543399,0.002296543,0.0007495264,0.001080886,0.002163805],"category_scores_gemma":[0.05862866,0.0004159822,0.002236332,0.001147793,0.001467881,0.001687127,0.001119465,0.00149074,0.0003808964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008574582,"about_ca_system_score_gemma":0.001689189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006326401,"about_ca_topic_score_gemma":0.001043244,"domain_scores_codex":[0.9683182,0.02736098,0.001612985,0.001154714,0.001117126,0.0004360285],"domain_scores_gemma":[0.8933316,0.0768437,0.01467167,0.009514516,0.003364434,0.002273972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2673237,0.005714773,0.5162452,0.004008863,0.01762111,0.0003530148,0.0006680513,0.00403481,0.002345923,0.001222921,0.002365756,0.1780959],"study_design_scores_gemma":[0.06316201,0.3105976,0.5209339,0.004139048,0.04930131,0.001837329,0.001519476,0.01147161,0.006424018,0.00447861,0.02574139,0.0003936449],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647808,0.02116461,0.005288629,0.001722611,0.0002302674,0.001563406,0.001565824,0.00002935352,0.003654594],"genre_scores_gemma":[0.9927502,0.002989929,0.002226927,0.0005677621,0.0001333513,0.0003820629,0.0008268082,0.00001121536,0.0001117462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04501821,"threshold_uncertainty_score":0.2380819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1342148052657563,"score_gpt":0.4158546229617893,"score_spread":0.281639817696033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}