{"id":"W4377014295","doi":"10.1212/wnl.0000000000207408","title":"Association of Cortical and Subcortical Microstructure With Clinical Progression and Fluid Biomarkers in Patients With Parkinson Disease","year":2023,"lang":"en","type":"article","venue":"Neurology","topic":"Advanced Neuroimaging Techniques and Applications","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Avid Radiopharmaceuticals; Sanofi Genzyme; Allergan; H. Lundbeck A/S; Higher Education Discipline Innovation Project; Servier; Genentech; National Natural Science Foundation of China; Voyager Therapeutics; Neurocrine Biosciences; Biogen; Celgene; Verily Life Sciences; Teva Pharmaceutical Industries; Sanofi; GlaxoSmithKline; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Internal medicine; Biomarker; Medicine; Montreal Cognitive Assessment; Parkinson's disease; Putamen; Diffusion MRI; Neurology; Psychology; Disease; Oncology; Cardiology; Magnetic resonance imaging; Psychiatry; Radiology; Cognitive impairment; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005703421,0.000268079,0.0002970664,0.0006324406,0.0003369645,0.0005828953,0.0002293346,0.0004081999,0.001056874],"category_scores_gemma":[0.002289194,0.0001806952,0.0002252988,0.0004540031,0.0002209906,0.0003653444,0.000320994,0.0004895196,0.0001106198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002975644,"about_ca_system_score_gemma":0.0002963208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004011356,"about_ca_topic_score_gemma":0.006922666,"domain_scores_codex":[0.9998061,0.00004282505,0.00002324192,0.00006399037,0.00003531196,0.00002862253],"domain_scores_gemma":[0.9989051,0.0002094672,0.00051239,0.00007594659,0.000189669,0.0001073798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003472264,0.00003211676,0.9969137,0.000009324599,0.00008034769,0.00008664333,0.0000635941,0.0000670453,0.0005481539,0.00001962648,0.00006388831,0.001768409],"study_design_scores_gemma":[0.000005494793,0.00007801967,0.999285,0.000002943126,0.00002050529,0.0002104443,0.00004277385,0.0001801179,0.00008141424,0.00003907759,0.00005222909,0.000001988162],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990627,0.0003319016,0.00008609616,0.00004080628,0.000002693456,0.000005621091,0.0001911061,0.000004081432,0.0002749277],"genre_scores_gemma":[0.9995818,0.00005022651,0.00009219138,0.00001036306,0.000004791644,0.000004599676,0.0001396948,0.000001091143,0.0001153398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004011356,"threshold_uncertainty_score":0.007976055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01979690020336478,"score_gpt":0.3407179896663006,"score_spread":0.3209210894629358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}