{"id":"W4377018335","doi":"10.1016/j.biopha.2023.114878","title":"Oral delivery of a highly stable superoxide dismutase as a skin aging inhibitor","year":2023,"lang":"en","type":"article","venue":"Biomedicine & Pharmacotherapy","topic":"Skin Protection and Aging","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cape Breton University","funders":"National Key Research and Development Program of China; National Key Laboratory Foundation of China; Natural Sciences and Engineering Research Council of Canada; China Ocean Mineral Resources Research and Development Association; Canada Research Chairs","keywords":"Superoxide dismutase; Bioavailability; Antioxidant; Skin Aging; In vivo; Chemistry; Pharmacology; Enzyme; In vitro; Biochemistry; Food science; Biology; Medicine; Biotechnology; Dermatology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004986755,0.0002393304,0.0004571444,0.0007120435,0.00009320877,0.00001328939,0.0001193912,0.00007064563,0.001162157],"category_scores_gemma":[0.00003340031,0.0001929252,0.0001445315,0.001490321,0.0001600308,0.0001226364,0.00003897225,0.0002282869,0.0001816895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008133801,"about_ca_system_score_gemma":0.0001516776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000578619,"about_ca_topic_score_gemma":0.000003351299,"domain_scores_codex":[0.998153,0.00006895336,0.0004579079,0.0003531267,0.0005311816,0.0004357918],"domain_scores_gemma":[0.9991499,0.00008605236,0.0001141138,0.0002574821,0.0001209095,0.0002715302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004994665,0.0001776637,0.002462035,0.0001465877,0.0001577453,0.0002347204,0.0008479527,0.000003875719,0.9294768,0.00002082028,0.02141817,0.04455419],"study_design_scores_gemma":[0.009776858,0.0005849502,0.003114432,0.0004477616,0.0001207262,0.0001246006,0.0006741886,0.0008827306,0.827588,0.00004925851,0.156399,0.0002375087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911783,0.001047001,0.000184949,0.005478462,0.0006436548,0.0005961244,0.00002371588,0.0004074239,0.0004403939],"genre_scores_gemma":[0.9910054,0.001001772,0.0003449947,0.00381528,0.0008306794,0.00005749446,0.00006881899,0.00006676495,0.002808848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1349808,"threshold_uncertainty_score":0.9997509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02476918679291539,"score_gpt":0.3370355253805956,"score_spread":0.3122663385876802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}