{"id":"W4377018442","doi":"10.1016/j.jtho.2023.03.003","title":"Response to a Letter Received Entitled: “‘Brief Report: Canadian Cancer Trials Group IND.227’: Unpacking the Clinical Potential of Single-Agent Pembrolizumab in Advanced Malignant Pleural Mesothelioma”","year":2023,"lang":"en","type":"letter","venue":"Journal of Thoracic Oncology","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; University of Alberta; Queen's University; Alberta Health Services","funders":"Canadian Cancer Society","keywords":"Medicine; Pembrolizumab; Mesothelioma; Oncology; Lung cancer; Internal medicine; Clinical trial; Cancer; Surgery; Pathology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003424783,0.0006873927,0.001259745,0.0006182704,0.004540362,0.002569652,0.001635523,0.04028163,0.008723634],"category_scores_gemma":[0.01671464,0.0006284084,0.001185995,0.0008321072,0.001564007,0.001574567,0.0008965028,0.02557295,0.008361687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009171048,"about_ca_system_score_gemma":0.009961207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05964129,"about_ca_topic_score_gemma":0.094259,"domain_scores_codex":[0.9973741,0.0006488237,0.0002886713,0.0003315223,0.0007970895,0.0005597933],"domain_scores_gemma":[0.9943527,0.002551111,0.0003591225,0.00009649882,0.001501881,0.001138625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007610906,0.0000140867,0.0002870157,0.00002192451,0.000006339914,0.0004782329,0.00004547012,0.00002386231,0.00009477229,0.0003523653,0.9967095,0.001890195],"study_design_scores_gemma":[0.0002329444,0.0001164146,0.002956199,0.0002626824,0.00003956844,0.00121422,0.000346666,0.0003952901,0.0003455972,0.002035797,0.991973,0.00008160968],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0004510408,0.0006051601,0.00005501631,0.9815589,0.01324466,0.00003588015,0.0003343569,0.00004631252,0.003668784],"genre_scores_gemma":[0.002261147,0.000358796,0.0001078133,0.9801354,0.007754325,0.00004446567,0.00009881043,0.00002509513,0.009214147],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.05964129,"threshold_uncertainty_score":0.1185883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08669132187558784,"score_gpt":0.4493201992237101,"score_spread":0.3626288773481222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}