{"id":"W4377019781","doi":"10.1038/s41589-023-01345-y","title":"Structural basis for Lewis antigen synthesis by the α1,3-fucosyltransferase FUT9","year":2023,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; U.S. Department of Health and Human Services; National Institutes of Health; National Center for Research Resources; National Institute of General Medical Sciences; Amgen","keywords":"Fucosyltransferase; Glycan; Biochemistry; Sialyltransferase; Glycosyltransferase; Chemistry; Biology; Enzyme; Glycoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002572267,0.0001846568,0.0001816409,0.00004845099,0.0001537118,0.00002180968,0.0004457558,0.0007797714,0.000113328],"category_scores_gemma":[0.001077448,0.0001230193,0.0001733757,0.0002477239,0.0001960152,0.000002888875,0.0001054464,0.000360886,0.00003245036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001639809,"about_ca_system_score_gemma":0.00005113377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001343495,"about_ca_topic_score_gemma":0.000009386101,"domain_scores_codex":[0.9986753,0.00008117483,0.0001854128,0.0004688464,0.0001203551,0.0004688787],"domain_scores_gemma":[0.9991722,0.0002155702,0.00003482253,0.0003557005,0.0001207391,0.0001010282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001560205,0.00001095009,0.0006487438,0.00001419613,0.00005769185,8.060209e-7,0.00001050208,0.000001080855,0.953558,0.0002240382,0.0351655,0.01015248],"study_design_scores_gemma":[0.000273137,0.00006646139,0.0003501792,0.000003620238,0.000008841409,0.00000721351,0.00001812987,0.00009517324,0.8209085,0.0002788009,0.1778417,0.0001482437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918754,0.001192466,0.0002203792,0.005046417,0.0001884844,0.0004585595,0.0006069193,0.00004839849,0.0003629891],"genre_scores_gemma":[0.9966498,0.0002526125,0.0001716389,0.0007903562,0.0003549474,0.0001828282,0.001186267,0.00002555308,0.0003860015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1426762,"threshold_uncertainty_score":0.6014311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01254390222247531,"score_gpt":0.3035549405534299,"score_spread":0.2910110383309546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}