{"id":"W4377020220","doi":"10.3390/chemosensors11050298","title":"Methods and Analysis of Biological Contaminants in the Biomanufacturing Industry","year":2023,"lang":"en","type":"article","venue":"Chemosensors","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; University of Calgary","keywords":"Biomanufacturing; Bioprocess; Biochemical engineering; Critical quality attributes; European union; Biotechnology; Risk analysis (engineering); Computer science; Biology; Engineering; Business; Downstream (manufacturing)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003030948,0.00007910343,0.0001442694,0.0001105994,0.00003836746,0.000008554735,0.00009877064,0.0001827276,0.00001384222],"category_scores_gemma":[0.0001328346,0.00005094765,0.00008243044,0.0004819245,0.00008384007,0.000001347667,0.00007782169,0.00008113218,0.000001281721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002657924,"about_ca_system_score_gemma":0.000007451156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002328723,"about_ca_topic_score_gemma":0.000007541729,"domain_scores_codex":[0.9993569,0.0001233058,0.0001405965,0.0001939437,0.00005340867,0.0001318555],"domain_scores_gemma":[0.9996583,0.00005456946,0.00005007989,0.000191472,0.00001507269,0.00003053561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003185546,0.00004110417,0.1268272,0.00001192699,0.0001832753,0.000007366389,0.000190457,0.0001516683,0.8671615,0.00001957991,0.0007853534,0.004588689],"study_design_scores_gemma":[0.000164029,0.00006058378,0.4655763,0.000005037308,0.00005222258,0.000002720407,0.0004157204,0.0001824041,0.5320744,0.00005958566,0.001330424,0.0000765626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993142,0.0001830463,0.00003425703,0.0000552992,0.00003962322,0.0000641608,0.00001401309,0.000008023949,0.000287302],"genre_scores_gemma":[0.9994065,0.0001449039,0.000156554,0.0001281779,0.00002659081,0.00001056289,0.00004623368,0.000004440211,0.00007609878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3387491,"threshold_uncertainty_score":0.2077585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03826961108815308,"score_gpt":0.3683001741717887,"score_spread":0.3300305630836356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}