{"id":"W4377023946","doi":"10.1016/j.jbc.2023.104840","title":"RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing","year":2023,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; Waksman Foundation of Japan; Nippon Foundation; Senri Life Science Foundation; National Institute of Genetics; Ministry of Education, Culture, Sports, Science and Technology; Osaka University; Astellas Pharma; Astellas Foundation for Research on Metabolic Disorders; Japan Intractable Diseases Research Foundation; Uehara Memorial Foundation; Japan Agency for Medical Research and Development; Moritani Scholarship Foundation; Takeda Science Foundation","keywords":"RNA editing; ADAR; RNA splicing; Biology; RNA; Intron; Exon; RNA silencing; Messenger RNA; Molecular biology; Coding region; Cell biology; Genetics; Gene; RNA interference","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001435138,0.0003131865,0.0002880072,0.0001675431,0.0001429479,0.000295214,0.0001672061,0.0002358543,0.0006314125],"category_scores_gemma":[0.00009949891,0.0001383256,0.0002958815,0.00009092969,0.0002015555,0.0001894109,0.000156681,0.0005659393,0.00031843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002269633,"about_ca_system_score_gemma":0.00008946589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002121943,"about_ca_topic_score_gemma":0.000346949,"domain_scores_codex":[0.9997985,0.00002292413,0.0000164147,0.00008227451,0.00004878021,0.0000311844],"domain_scores_gemma":[0.9998901,0.00001654428,0.00004586713,0.00001299493,0.00001289963,0.00002155847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002001649,0.000002048196,0.00006277826,0.000007199756,9.992958e-7,0.00001528821,0.000003858507,0.000006586095,0.9996812,0.00001644903,0.000004771272,0.0001788481],"study_design_scores_gemma":[0.000003625275,0.0000702531,0.002470428,0.000002040042,0.000006530968,0.0001426059,0.00000775338,0.0002885441,0.996204,0.00001625241,0.0007858177,0.000002068188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894664,0.001849286,0.006871542,0.00007804781,0.00003989882,0.00002370182,0.0002730011,0.0001211845,0.001276915],"genre_scores_gemma":[0.9930248,0.000561006,0.003666634,0.0000609403,0.00001749851,0.00002334363,0.0005609677,0.00003289609,0.002051857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006314125,"threshold_uncertainty_score":0.002112329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01617747543832442,"score_gpt":0.2621823479564758,"score_spread":0.2460048725181513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}