{"id":"W4377024670","doi":"10.20944/preprints202305.0983.v1","title":"Effect of Hesperidin on Barrier Function and Reactive Oxygen Species Production in an Oral Epithelial Cell Model, and on Se-Cretion of Macrophage-Derived Inflammatory Mediators During Porphyromonas gingivalis Infection","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Universitetet i Oslo","keywords":"Porphyromonas gingivalis; Hesperidin; Reactive oxygen species; Chemistry; Barrier function; Matrix metalloproteinase; Secretion; Inflammation; Microbiology; Periodontitis; Immunology; Cell biology; Biology; Medicine; Biochemistry; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002610255,0.0003322648,0.0003814004,0.0002164004,0.0001491378,0.0002098907,0.0001148478,0.000302447,0.000667092],"category_scores_gemma":[0.000184144,0.0001262287,0.0002641051,0.0001623472,0.0002035777,0.000326868,0.0001788377,0.0004778682,0.00009904065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001222755,"about_ca_system_score_gemma":0.0001391676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002415893,"about_ca_topic_score_gemma":0.0003061193,"domain_scores_codex":[0.9998504,0.00003848441,0.00002083023,0.00002827084,0.0000314558,0.00003047272],"domain_scores_gemma":[0.9998678,0.00003126798,0.00003323825,0.00001304015,0.00002542212,0.00002919771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001164603,0.0002657843,0.0002078297,0.000181475,0.00000975303,0.0001064521,0.00005811907,0.00007083503,0.9954545,0.00003464281,0.00004788977,0.002398052],"study_design_scores_gemma":[0.00006040838,0.003733197,0.009365761,0.00001807486,0.00004200872,0.0002521324,0.0001333805,0.0008765018,0.9835464,0.00006240363,0.00189685,0.00001294818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960347,0.002559119,0.0005938578,0.00005747336,0.00004403753,0.00003440542,0.0001319652,0.00002049274,0.0005239354],"genre_scores_gemma":[0.9950063,0.001697951,0.00172381,0.00005778772,0.00002074482,0.00006415915,0.000185002,0.000005848957,0.001238306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000667092,"threshold_uncertainty_score":0.002231658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06273636015302105,"score_gpt":0.3324010817803457,"score_spread":0.2696647216273246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}