{"id":"W4377024670","doi":"10.20944/preprints202305.0983.v1","title":"Effect of Hesperidin on Barrier Function and Reactive Oxygen Species Production in an Oral Epithelial Cell Model, and on Se-Cretion of Macrophage-Derived Inflammatory Mediators During Porphyromonas gingivalis Infection","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Universitetet i Oslo","keywords":"Porphyromonas gingivalis; Hesperidin; Reactive oxygen species; Chemistry; Barrier function; Matrix metalloproteinase; Secretion; Inflammation; Microbiology; Periodontitis; Immunology; Cell biology; Biology; Medicine; Biochemistry; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001419128,0.00038619,0.0006247129,0.0006185279,0.0001312762,0.00002483388,0.0001550899,0.0006020838,0.0001151615],"category_scores_gemma":[0.0004004059,0.000388525,0.0001422395,0.000176943,0.0003219766,0.0002431009,0.0005599031,0.001063277,0.00007011022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002044142,"about_ca_system_score_gemma":0.00007341529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006117662,"about_ca_topic_score_gemma":0.0003296988,"domain_scores_codex":[0.9967914,0.0009944128,0.0005697999,0.001047537,0.0003051555,0.0002917211],"domain_scores_gemma":[0.9986154,0.0001178033,0.0004162589,0.0006026431,0.0001455955,0.0001022544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002272906,0.00006837364,0.4241789,0.0007165216,0.00006387436,0.00001325184,0.0006022738,0.002854784,0.5691222,0.000008402242,0.000002533639,0.00009592956],"study_design_scores_gemma":[0.0005245894,0.0002365484,0.5103536,0.000178969,0.00003803332,0.000004811386,0.00003213047,0.0001533922,0.4881944,0.0001290181,0.000003606034,0.0001508419],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975589,0.00004522628,0.000005931802,0.00002565816,0.0009397427,0.001067454,0.000162547,0.00009317294,0.0001014006],"genre_scores_gemma":[0.9985459,0.0002833702,0.00001071801,0.000003517777,0.0001757636,0.0001123519,0.0001965708,0.00005991781,0.0006118611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08617471,"threshold_uncertainty_score":0.9998567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06273636015302105,"score_gpt":0.3324010817803457,"score_spread":0.2696647216273246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}