{"id":"W4377042426","doi":"10.3390/vaccines11050991","title":"IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein","year":2023,"lang":"en","type":"review","venue":"Vaccines","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services","funders":"","keywords":"Vaccination; Immunology; Medicine; Immune system; Immunity; Antibody; Antigen; Virology; Population; Pertussis vaccine; Immunization; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007374826,0.0008430923,0.001825553,0.0003763017,0.0007383022,0.0001081421,0.001238815,0.0007342592,0.0001046346],"category_scores_gemma":[0.0002745455,0.0005572297,0.0005289288,0.001369234,0.00003668867,0.00014445,0.0003545499,0.0008573402,0.003513853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007264199,"about_ca_system_score_gemma":0.0001669583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004491191,"about_ca_topic_score_gemma":0.00002175825,"domain_scores_codex":[0.9962729,0.0006439045,0.001313233,0.0008782259,0.0000895742,0.0008021664],"domain_scores_gemma":[0.9978351,0.0001289795,0.0006786988,0.001162745,0.0001866135,0.000007866606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007489868,0.0001624185,0.000001452161,0.002870645,0.0006487677,0.000008294443,0.000423966,0.000004961407,0.1632249,0.0001490525,0.01157837,0.8208523],"study_design_scores_gemma":[0.0005141879,0.0001142764,0.00008083141,0.003164623,0.0002680139,0.00003552077,0.00008137245,0.000002357246,0.02209977,0.00001738098,0.9729012,0.000720474],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01382409,0.9801991,0.00001678259,0.000536655,0.001963826,0.002704233,0.0001536663,0.0003793129,0.000222326],"genre_scores_gemma":[0.008082567,0.9785053,0.000007630132,0.0001843399,0.00004045606,0.0008525893,0.001349306,0.0001523649,0.01082543],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9613228,"threshold_uncertainty_score":0.9996879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05131350731791028,"score_gpt":0.3262301602016541,"score_spread":0.2749166528837438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}