{"id":"W4377042426","doi":"10.3390/vaccines11050991","title":"IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein","year":2023,"lang":"en","type":"review","venue":"Vaccines","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services","funders":"","keywords":"Vaccination; Immunology; Medicine; Immune system; Immunity; Antibody; Antigen; Virology; Population; Pertussis vaccine; Immunization; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007993291,0.0004826636,0.0003937332,0.000333954,0.0001544794,0.0003125279,0.0002713434,0.000776445,0.001756349],"category_scores_gemma":[0.0007027716,0.0002298663,0.0005943513,0.0001224293,0.0002959489,0.0002436188,0.0003074472,0.0008898053,0.0003964812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004873589,"about_ca_system_score_gemma":0.000299941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006216372,"about_ca_topic_score_gemma":0.0003775976,"domain_scores_codex":[0.99957,0.0001044955,0.0000282929,0.00006136877,0.00008574326,0.0001501206],"domain_scores_gemma":[0.9996648,0.00007377478,0.0001112437,0.00005920128,0.00005014487,0.00004089358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009068992,0.0004526706,0.01337964,0.0003146328,0.0001403637,0.00114372,0.0001554233,0.0002665249,0.954717,0.0007073356,0.0004695227,0.0273463],"study_design_scores_gemma":[0.0004751706,0.01334164,0.2435047,0.0001201409,0.0004502185,0.007565141,0.0003128596,0.003574114,0.7132853,0.002754751,0.01457388,0.00004193743],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9917783,0.002664915,0.002453011,0.0002651123,0.0001200632,0.00009263053,0.00004337243,0.0001695819,0.002413012],"genre_scores_gemma":[0.9979486,0.0003390679,0.000432728,0.0002486153,0.00004403161,0.00002456227,0.00005269989,0.00001249288,0.0008974031],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001756349,"threshold_uncertainty_score":0.005875528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05131350731791028,"score_gpt":0.3262301602016541,"score_spread":0.2749166528837438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}