{"id":"W4377086952","doi":"10.1101/2023.05.17.23290141","title":"Effect of Time to Thrombolysis on Clinical Outcomes in Patients with Acute Ischemic Stroke Treated with Tenecteplase Compared to Alteplase: Analysis from the AcT Randomized Controlled Trial","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Red Deer Regional Hospital; Medicine Hat Regional Hospital; Manitoba Health; London Health Sciences Centre; University of British Columbia; University of Ottawa; McMaster University; Western University; University of Toronto; Université de Sherbrooke; Queen's University; Ottawa Hospital; Health Sciences Centre; St. Michael's Hospital; Sunnybrook Health Science Centre; Kelowna General Hospital; University of Manitoba; Queen Elizabeth II Health Sciences Centre; Grey Nuns Community Hospital; University of Alberta; University of Saskatchewan; Université de Montréal; University of Calgary","funders":"Biogen","keywords":"Tenecteplase; Medicine; Thrombolysis; Modified Rankin Scale; Stroke (engine); Randomized controlled trial; Fibrinolytic agent; Tissue plasminogen activator; Intracerebral hemorrhage; Odds ratio; Internal medicine; Ischemic stroke; Subarachnoid hemorrhage; Ischemia; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01334169,0.001750137,0.0056052,0.0009117624,0.0004561213,0.002324929,0.001299212,0.002020863,0.005536152],"category_scores_gemma":[0.02871254,0.0005784098,0.01078968,0.001607315,0.00116038,0.001695702,0.0008501302,0.002852183,0.0003994424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009334396,"about_ca_system_score_gemma":0.001319912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001724322,"about_ca_topic_score_gemma":0.001782124,"domain_scores_codex":[0.9808547,0.01451546,0.001888492,0.001244854,0.001012066,0.0004843489],"domain_scores_gemma":[0.9727381,0.01721431,0.006420138,0.001213913,0.001193449,0.001220141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9434841,0.0006759973,0.006356597,0.00430009,0.03751332,0.00006006764,0.00006674536,0.0004473726,0.0002821751,0.0003015925,0.0007278004,0.005784069],"study_design_scores_gemma":[0.8390821,0.03228449,0.03214901,0.001008286,0.08865623,0.0001324191,0.0001278121,0.002947819,0.0003980048,0.001388676,0.001715568,0.0001094879],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9329215,0.04900635,0.003317221,0.001448061,0.001483815,0.003833811,0.00395814,0.0001491549,0.003881988],"genre_scores_gemma":[0.9824073,0.006457929,0.001931781,0.0009936757,0.0007469523,0.003991982,0.002291798,0.00004571489,0.001132925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01334169,"threshold_uncertainty_score":0.07055849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464808030644697,"score_gpt":0.3087641823086459,"score_spread":0.2941161020021989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}