{"id":"W4377087661","doi":"10.1200/edbk_390384","title":"Genetic and Genomic Testing for Prostate Cancer: Beyond DNA Repair","year":2023,"lang":"en","type":"article","venue":"American Society of Clinical Oncology Educational Book","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"","keywords":"Prostate cancer; Medicine; DNA repair; Genetic testing; Precision medicine; Disease; Personalized medicine; Clinical trial; Cancer; MSH2; Germline; Microsatellite instability; Oncology; DNA mismatch repair; Bioinformatics; Internal medicine; Biology; Gene; Genetics; Pathology; Colorectal cancer; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005941435,0.0001037349,0.0005247271,0.00003471566,0.0001064037,0.000003758587,0.00006339288,0.00008150438,0.00007205115],"category_scores_gemma":[0.0005178218,0.00008675917,0.0002733077,0.0002532279,0.001336188,0.0000306753,0.00005558131,0.0001818425,0.00001206863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001772777,"about_ca_system_score_gemma":0.003892176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001420234,"about_ca_topic_score_gemma":0.0000058152,"domain_scores_codex":[0.9986123,0.00005988033,0.0005605523,0.0003404215,0.000155173,0.0002716644],"domain_scores_gemma":[0.9955156,0.003530905,0.0002978774,0.0001451225,0.0003083798,0.0002020807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003511318,0.0003131195,0.6560584,0.0001454741,0.0003733516,0.000001969839,0.0005897998,0.000007501948,0.00128062,0.00006444957,0.1110369,0.2297773],"study_design_scores_gemma":[0.001825193,0.002327405,0.866362,0.00003720917,0.0001416556,0.000006424735,0.000657088,0.0007540736,0.00004488178,0.0006229202,0.1271347,0.00008646166],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.929271,0.001837039,0.00000552456,0.06659575,0.0001783512,0.000814468,0.00005048091,0.00005554498,0.001191874],"genre_scores_gemma":[0.6731175,0.02983577,0.1545144,0.03156569,0.003750243,0.002687334,0.0003473182,0.0001272332,0.1040546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2561535,"threshold_uncertainty_score":0.6904553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.106538053875414,"score_gpt":0.486012156683782,"score_spread":0.379474102808368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}