{"id":"W4377088076","doi":"10.1126/sciadv.adg2379","title":"Molecular evolution of Keap1 was essential for adaptation of vertebrates to terrestrial life","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Science and Technology Agency; Japan Society for the Promotion of Science; Institute of Genetics; Japan Agency for Medical Research and Development","keywords":"KEAP1; Zebrafish; Biology; Adaptation (eye); Mutant; Ubiquitin ligase; Genetics; Transcription factor; Reactive oxygen species; Gene; Ubiquitin; Evolutionary biology; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000181526,0.00006754649,0.0001050072,0.00008224201,0.00005377351,0.000007495575,0.0002311083,0.00003217552,0.000001440746],"category_scores_gemma":[0.0005328073,0.00006527612,0.00005056566,0.0003239034,0.0002768867,0.00001454735,0.00006718843,0.00001639379,0.000002051185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001003318,"about_ca_system_score_gemma":0.0001817008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001423748,"about_ca_topic_score_gemma":0.00001355732,"domain_scores_codex":[0.9992343,0.00001184719,0.0001733222,0.0002563341,0.0001533769,0.0001708364],"domain_scores_gemma":[0.9995382,0.00001451504,0.0001002337,0.000150488,0.0001367568,0.00005981003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000936121,0.00001512678,0.0004310706,0.00001765211,0.000005421029,7.518322e-8,0.00007934044,0.006245364,0.9913155,0.0001164509,0.00005409972,0.001626282],"study_design_scores_gemma":[0.000280697,0.0001985668,0.0008306771,0.00001210415,0.000006048731,1.477189e-7,0.0005491036,0.0009112449,0.9956089,0.0008403869,0.0006873796,0.00007471503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680045,0.000395256,0.03097612,0.00006758349,0.000263293,0.0002049764,0.0000316489,0.000005763377,0.00005091834],"genre_scores_gemma":[0.9971831,0.00002439276,0.002602592,0.00001786132,0.00009286735,0.00002275198,0.00003434618,0.000005182018,0.00001688876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02917868,"threshold_uncertainty_score":0.2661883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277384704084553,"score_gpt":0.2894552447340222,"score_spread":0.2766813976931767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}