{"id":"W4377088076","doi":"10.1126/sciadv.adg2379","title":"Molecular evolution of Keap1 was essential for adaptation of vertebrates to terrestrial life","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Science and Technology Agency; Japan Society for the Promotion of Science; Institute of Genetics; Japan Agency for Medical Research and Development","keywords":"KEAP1; Zebrafish; Biology; Adaptation (eye); Mutant; Ubiquitin ligase; Genetics; Transcription factor; Reactive oxygen species; Gene; Ubiquitin; Evolutionary biology; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001600627,0.0002337909,0.0001861911,0.000196496,0.0002810428,0.00026568,0.0002399471,0.0004132988,0.001185092],"category_scores_gemma":[0.0001512116,0.0001453374,0.0002608461,0.0001492309,0.0002702528,0.0003159404,0.000314411,0.0007603141,0.000380689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003573891,"about_ca_system_score_gemma":0.0002806647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006283273,"about_ca_topic_score_gemma":0.0007981402,"domain_scores_codex":[0.9999114,0.000007655344,0.000008489758,0.0000383678,0.00001813369,0.0000159598],"domain_scores_gemma":[0.9998711,0.00001703908,0.00004401935,0.0000174958,0.00001805247,0.0000323882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007322164,0.000005567915,0.001510845,0.00003362709,0.000007625971,0.0001807565,0.00002135675,0.00009269387,0.9957594,0.0002696464,0.00002141056,0.002023815],"study_design_scores_gemma":[0.00001764592,0.0002068372,0.09934847,0.00002487861,0.00006470916,0.002390594,0.0001092969,0.002074645,0.8829669,0.0005352494,0.01223454,0.00002617208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929832,0.001162381,0.003783726,0.000193671,0.00003674875,0.00001279366,0.0003617789,0.00007139567,0.001394317],"genre_scores_gemma":[0.9937652,0.0005750597,0.002650097,0.00007292004,0.000009409661,0.000009774082,0.0003521728,0.00002710459,0.00253822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001185092,"threshold_uncertainty_score":0.003964543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277384704084553,"score_gpt":0.2894552447340222,"score_spread":0.2766813976931767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}