{"id":"W4377088110","doi":"10.1126/sciadv.adf8169","title":"Structure of the immunoregulatory sialidase NEU1","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; McGill University","funders":"Argonne National Laboratory; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Office of Science; National Institutes of Health; U.S. Department of Energy","keywords":"Sialidase; Neuraminidase; Cathepsin A; Glycan; Enzyme; Biochemistry; Cell biology; Chemistry; Sialic acid; Glycoprotein; Biology; Cathepsin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001610353,0.00004517659,0.00004146257,0.00004720253,0.0001660132,0.00001530214,0.0004207249,0.00002398746,0.00002321559],"category_scores_gemma":[0.0001675144,0.00002863104,0.0000309633,0.0006974756,0.0006268868,0.0000100742,0.0001699781,0.00004084442,0.000006849116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005151509,"about_ca_system_score_gemma":0.0001380687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004921815,"about_ca_topic_score_gemma":0.00001660037,"domain_scores_codex":[0.9992808,0.00001917198,0.00007669999,0.0001677967,0.0002902923,0.0001652133],"domain_scores_gemma":[0.9995314,0.000004737908,0.00003835448,0.0003057883,0.00008842529,0.0000313334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006708268,0.000002784315,0.001574476,0.000004956869,0.000001078721,1.803607e-7,0.00002024643,0.0003548127,0.9899336,0.0001321271,0.0000952254,0.007873802],"study_design_scores_gemma":[0.00007791594,0.00002934473,0.02368647,0.00000429282,6.107218e-7,0.00000147758,0.00007161872,0.0000353826,0.9528683,0.000393418,0.02279234,0.00003882741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987587,0.0003735623,0.00001352922,0.0001494905,0.0001843437,0.00009562333,0.00001059733,0.000006887072,0.0004072294],"genre_scores_gemma":[0.999096,0.00002741563,0.00007760566,0.00004513487,0.00003703129,0.000002370746,0.00000419981,0.000003136716,0.0007071464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03706529,"threshold_uncertainty_score":0.2309791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007935206321800978,"score_gpt":0.2964292534487985,"score_spread":0.2884940471269975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}