{"id":"W4377088304","doi":"10.1523/jneurosci.2312-22.2023","title":"Elevated Galectin-3 Is Associated with Aging, Multiple Sclerosis, and Oxidized Phosphatidylcholine-Induced Neurodegeneration","year":2023,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Multiple Sclerosis Society of Canada; Government of Canada; University of Saskatchewan","keywords":"Neurodegeneration; Multiple sclerosis; Neuroinflammation; Microglia; Experimental autoimmune encephalomyelitis; Neuroprotection; Spinal cord; Medicine; White matter; Biology; Immunology; Pathology; Neuroscience; Inflammation; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004177918,0.0001355401,0.0002500317,0.0001804723,0.0002714843,0.00004140315,0.0001970456,0.00009861038,0.0000175177],"category_scores_gemma":[0.0005675431,0.0001003184,0.00004723213,0.0007375872,0.0001549663,0.0001702607,0.00004695524,0.0003284336,0.000008907235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002476062,"about_ca_system_score_gemma":0.0001057465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000192077,"about_ca_topic_score_gemma":0.00002627298,"domain_scores_codex":[0.9988518,0.0001756012,0.0003155449,0.0002578676,0.00008453421,0.0003146446],"domain_scores_gemma":[0.999109,0.0001333457,0.0004022279,0.0001182911,0.0001954805,0.00004160876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009064146,0.00004217954,0.01129034,0.000002182083,0.00001356265,0.00001499786,0.0001546001,0.00002047878,0.9866796,0.000004873007,0.001072,0.0006145235],"study_design_scores_gemma":[0.002251126,0.0009637724,0.3652928,0.0000449584,0.00002798829,0.0003290807,0.0000404322,0.0001925106,0.6290889,0.00001225238,0.001621745,0.0001345419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978877,0.0002710707,0.00005238022,0.0006336562,0.0009926914,0.00009246297,0.000007544294,0.00004405595,0.00001838569],"genre_scores_gemma":[0.998212,0.0003814593,0.00001972459,0.0009338218,0.00003051942,0.000002983029,0.000003896444,0.00001220416,0.0004033414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3575908,"threshold_uncertainty_score":0.4090865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0464497423728684,"score_gpt":0.2591569520693469,"score_spread":0.2127072096964785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}