{"id":"W4377092852","doi":"10.1002/alz.13134","title":"Alzheimer's disease brain‐derived extracellular vesicles reveal altered synapse‐related proteome and induce cognitive impairment in mice","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Occupational Cancer Research Centre; University of Toronto","funders":"Institute for Translational Neuroscience; International Society for Neurochemistry; Universidade Federal do Rio de Janeiro; National Institute on Aging; Ministério da Saúde; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Universidade de São Paulo; University of Toronto","keywords":"Neuropathology; Extracellular vesicles; Synapse; Neuroscience; Dementia; Cognitive impairment; Memory impairment; Proteome; Frontotemporal dementia; Biology; Medicine; Disease; Cognition; Cell biology; Pathology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003346386,0.001005546,0.0005560075,0.001279108,0.00037427,0.0006880708,0.000419125,0.001145985,0.001868337],"category_scores_gemma":[0.0001815816,0.0004379283,0.001149793,0.0003777229,0.0004638894,0.0005952193,0.0005696029,0.001785061,0.001059287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006432508,"about_ca_system_score_gemma":0.0002902917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008706926,"about_ca_topic_score_gemma":0.001105928,"domain_scores_codex":[0.9996741,0.0000248772,0.00004970113,0.00009361023,0.00005862662,0.00009911379],"domain_scores_gemma":[0.9996753,0.00003068479,0.0001242762,0.00003419358,0.00003589928,0.00009971575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006293849,0.0002170582,0.0005441487,0.00009012136,0.00004724754,0.0001684159,0.00008144591,0.0001015828,0.9965315,0.0001788717,0.0001634366,0.001246692],"study_design_scores_gemma":[0.0001510345,0.002181739,0.02422853,0.00007313796,0.0001786788,0.001222603,0.0002219837,0.001711887,0.9649869,0.0004827716,0.004524428,0.00003636364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881429,0.001396087,0.002988133,0.0002839855,0.00009755749,0.0001107092,0.004901645,0.0002776312,0.001801408],"genre_scores_gemma":[0.978884,0.001929422,0.003819842,0.0002943705,0.000033419,0.0003964124,0.005684796,0.0001849309,0.008772809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001868337,"threshold_uncertainty_score":0.006250203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01714679147514003,"score_gpt":0.2636475380008754,"score_spread":0.2465007465257354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}