{"id":"W4377092852","doi":"10.1002/alz.13134","title":"Alzheimer's disease brain‐derived extracellular vesicles reveal altered synapse‐related proteome and induce cognitive impairment in mice","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Occupational Cancer Research Centre; University of Toronto","funders":"Institute for Translational Neuroscience; International Society for Neurochemistry; Universidade Federal do Rio de Janeiro; National Institute on Aging; Ministério da Saúde; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Universidade de São Paulo; University of Toronto","keywords":"Neuropathology; Extracellular vesicles; Synapse; Neuroscience; Dementia; Cognitive impairment; Memory impairment; Proteome; Frontotemporal dementia; Biology; Medicine; Disease; Cognition; Cell biology; Pathology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005504203,0.0004333238,0.000293501,0.0001812867,0.0001670804,0.0000725572,0.0003289151,0.0002254043,0.00006661772],"category_scores_gemma":[0.0001278245,0.0004800034,0.0001467736,0.0003848894,0.0002709917,0.00003151946,0.0004554444,0.0002385193,0.0001171007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007446463,"about_ca_system_score_gemma":0.0001483112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004859058,"about_ca_topic_score_gemma":0.00002447091,"domain_scores_codex":[0.9970402,0.0003340397,0.0005997243,0.001000394,0.0003040333,0.0007215807],"domain_scores_gemma":[0.9987217,0.00006010439,0.000211603,0.0004814529,0.00008865761,0.0004365239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005240574,0.0004021544,0.009568635,0.00002807969,0.005790334,0.0003455183,0.0003279831,0.00003921579,0.9752563,0.00006404767,0.002453987,0.005199663],"study_design_scores_gemma":[0.003987764,0.0004454876,0.2350659,0.0001584251,0.006808616,0.00003029671,0.0004380118,0.0004657284,0.7496145,0.0005905521,0.001225369,0.00116938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8789777,0.1186304,0.0000426673,0.0006074929,0.0001616235,0.001340108,0.00009173636,0.0000819856,0.00006627892],"genre_scores_gemma":[0.997542,0.0002932386,0.0002832387,0.0004133059,0.0001337636,0.0003164063,0.0008828279,0.00009233871,0.0000428495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2256419,"threshold_uncertainty_score":0.9997652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01714679147514003,"score_gpt":0.2636475380008754,"score_spread":0.2465007465257354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}