{"id":"W4377093889","doi":"10.1186/s40170-023-00306-2","title":"Safety, tolerability, and effectiveness of the sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin in combination with standard chemotherapy for patients with advanced, inoperable pancreatic adenocarcinoma: a phase 1b observational study","year":2023,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Memorial University of Newfoundland","funders":"National Cancer Institute; National Institutes of Health; Michael Smith Health Research BC; American Heart Association; Alvin J. Siteman Cancer Center; Foundation for Barnes-Jewish Hospital","keywords":"Dapagliflozin; Tolerability; Medicine; Observational study; Internal medicine; Chemotherapy; Oncology; Adverse effect; Diabetes mellitus; Type 2 diabetes; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008776867,0.0002132087,0.0009067099,0.0001344519,0.000123015,0.00001217829,0.0001121962,0.00007401512,0.00002606009],"category_scores_gemma":[0.00009801247,0.0001286412,0.00004873454,0.0006682621,0.0002393004,0.0001574083,0.00003018767,0.0001953834,4.552249e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002120626,"about_ca_system_score_gemma":0.0005717872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001825823,"about_ca_topic_score_gemma":0.0001823645,"domain_scores_codex":[0.9981212,0.0002253272,0.0004073196,0.0003961166,0.0005430155,0.0003070025],"domain_scores_gemma":[0.9985233,0.0004016481,0.0001397445,0.0003149544,0.0005295149,0.00009086855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02001899,0.002204464,0.9714054,0.0004791786,0.0002322284,0.000004324346,0.00177443,0.0000288884,0.0007859424,0.0001201784,0.00001752325,0.002928453],"study_design_scores_gemma":[0.07432171,0.002820692,0.9192126,0.0003893547,0.0003680214,0.000001296312,0.0003403926,0.0002435387,0.001744719,0.0001787248,0.0002453729,0.0001335092],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927344,0.000707078,0.0001722561,0.0003730797,0.00009591373,0.005680973,0.0001874046,0.00002355379,0.00002535991],"genre_scores_gemma":[0.9977781,0.0002075468,0.0003232091,0.00008669343,0.00004473384,0.001362046,0.00009221411,0.0000347835,0.00007071312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05430271,"threshold_uncertainty_score":0.5245837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02992456890926547,"score_gpt":0.3425159202851841,"score_spread":0.3125913513759186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}