{"id":"W4377093889","doi":"10.1186/s40170-023-00306-2","title":"Safety, tolerability, and effectiveness of the sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin in combination with standard chemotherapy for patients with advanced, inoperable pancreatic adenocarcinoma: a phase 1b observational study","year":2023,"lang":"en","type":"article","venue":"Cancer & Metabolism","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Memorial University of Newfoundland","funders":"National Cancer Institute; National Institutes of Health; Michael Smith Health Research BC; American Heart Association; Alvin J. Siteman Cancer Center; Foundation for Barnes-Jewish Hospital","keywords":"Dapagliflozin; Tolerability; Medicine; Observational study; Internal medicine; Chemotherapy; Oncology; Adverse effect; Diabetes mellitus; Type 2 diabetes; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00472567,0.0006677598,0.001638817,0.0003881597,0.0004192089,0.000949138,0.0005877183,0.0008730628,0.001203831],"category_scores_gemma":[0.004601888,0.0004420983,0.00245384,0.0006251002,0.0007043835,0.0009702945,0.0004303595,0.001975158,0.0003053626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009959366,"about_ca_system_score_gemma":0.0009775059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007513969,"about_ca_topic_score_gemma":0.0008682668,"domain_scores_codex":[0.9978486,0.001067817,0.0002209525,0.0004117988,0.0003181355,0.000132781],"domain_scores_gemma":[0.9950625,0.001141113,0.002407006,0.0004059947,0.0003117458,0.0006715144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5901826,0.02100248,0.3230089,0.0007498622,0.008036561,0.0002597296,0.0003064757,0.001486518,0.009176116,0.00007430166,0.001788526,0.04392796],"study_design_scores_gemma":[0.1191745,0.3662578,0.4963286,0.0001171865,0.006560618,0.0006814008,0.0002020963,0.004354423,0.003213405,0.0002348698,0.002793576,0.00008161095],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974579,0.001005662,0.0002457234,0.00008041533,0.00001805139,0.000238448,0.0006372309,0.0000120695,0.0003044421],"genre_scores_gemma":[0.9979507,0.0003656264,0.0002401067,0.0001547765,0.00004764669,0.0001793916,0.0009455049,0.000005470307,0.0001107854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00472567,"threshold_uncertainty_score":0.02499199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02992456890926547,"score_gpt":0.3425159202851841,"score_spread":0.3125913513759186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}