{"id":"W4377098501","doi":"10.1101/2023.05.17.541173","title":"Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Biotechnology and Biological Sciences Research Council; Innovative Medicines Initiative; European Commission; European Federation of Pharmaceutical Industries and Associations; McGill University; Diamond Light Source; Wellcome Trust","keywords":"Proline; Transporter; Amino acid; Biochemistry; Chemistry; Cytoplasm; Receptor; Missense mutation; Protein structure; Coronavirus disease 2019 (COVID-19); Biology; Cell biology; Mutation; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001302412,0.0002776416,0.0004549567,0.0002852706,0.0003541008,0.0004519745,0.0004003167,0.0005434246,0.001428703],"category_scores_gemma":[0.0002380578,0.0001798309,0.000305767,0.0002737653,0.0002245328,0.0001904916,0.000203217,0.0004933468,0.0004181666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007515527,"about_ca_system_score_gemma":0.0001421552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002950978,"about_ca_topic_score_gemma":0.001725658,"domain_scores_codex":[0.9998866,0.00001284807,0.00000736609,0.0000279149,0.00004399066,0.00002120822],"domain_scores_gemma":[0.9998705,0.00002184041,0.0000406376,0.000008665439,0.00002194366,0.00003634029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004593783,0.00003766278,0.005124947,0.00008332473,0.00004991716,0.001272073,0.000146875,0.0005539437,0.990757,0.0003009087,0.0004190908,0.0007948366],"study_design_scores_gemma":[0.0001723361,0.0004063573,0.1435822,0.00004272311,0.0001221131,0.00767909,0.0009796498,0.08222631,0.7552741,0.00049583,0.008918428,0.0001008505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983603,0.000386087,0.0004077141,0.0001736655,0.00001090695,0.000002518542,0.0002688348,0.00003070218,0.0003591542],"genre_scores_gemma":[0.9968678,0.0002065164,0.0007265554,0.0000575018,0.000009134995,0.00000312609,0.001223045,0.00001800626,0.0008881295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002950978,"threshold_uncertainty_score":0.0058676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01603108518130009,"score_gpt":0.2199926453823942,"score_spread":0.2039615602010942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}