{"id":"W4377101446","doi":"10.1016/j.freeradbiomed.2023.03.165","title":"Overexpression of tau protein induces oxidative stress in SH-SY5Y cells, which is mitigated by redox-active nanoparticles","year":2023,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Biochemical effects in animals","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"SH-SY5Y; Oxidative stress; Redox; Chemistry; Cell biology; Oxidative phosphorylation; Nanoparticle; Biophysics; Biochemistry; Nanotechnology; Biology; Materials science; Cell culture; Genetics; Inorganic chemistry; Neuroblastoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003744007,0.0001981641,0.0006160272,0.0001478238,0.00004217208,0.000001734293,0.0001485018,0.0004579427,0.0002286929],"category_scores_gemma":[0.001785318,0.0001328884,0.00003053539,0.000623538,0.001217044,0.00003804662,0.0001312975,0.0004630203,0.000008075212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003267753,"about_ca_system_score_gemma":0.00006457874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002392583,"about_ca_topic_score_gemma":0.000009130066,"domain_scores_codex":[0.9984151,0.000200234,0.0004102926,0.000426578,0.0001981224,0.0003496892],"domain_scores_gemma":[0.9988799,0.0004071981,0.0001324869,0.0002613493,0.00007864702,0.0002404327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006673246,0.0001805971,0.001726996,0.0001848679,0.00005829579,0.0000159925,0.0005429406,5.989148e-8,0.9777216,0.0002410468,0.01670935,0.001950954],"study_design_scores_gemma":[0.003545879,0.001655979,0.005500834,0.00164046,0.00004031112,0.000006453732,0.0003545805,0.00005587793,0.9848305,0.001436658,0.0008096048,0.0001228597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892031,0.001118577,0.000005151352,0.00837835,0.00006941141,0.0005912174,0.0001709111,0.00005776814,0.0004055467],"genre_scores_gemma":[0.9985726,0.0002624454,0.0001666719,0.000494648,0.0001077103,0.00005114002,0.0001771014,0.00001428216,0.000153433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01589974,"threshold_uncertainty_score":0.5419033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561825656490965,"score_gpt":0.3016030713484245,"score_spread":0.2859848147835148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}