{"id":"W4377103533","doi":"10.3389/fgene.2023.1093882","title":"Genome-wide search identified DNA methylation sites that regulate the metabolome","year":2023,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Compute Canada","keywords":"Metabolome; Biology; DNA methylation; Methylation; Transcriptome; CpG site; Genetics; Metabolomics; Gene; Computational biology; Bioinformatics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006076136,0.0003343293,0.0005548926,0.0012976,0.0003766241,0.0004256865,0.0003163944,0.0003928444,0.004706512],"category_scores_gemma":[0.001111904,0.0001745245,0.0009309935,0.001661436,0.0001589034,0.0001315243,0.0003958632,0.0004280734,0.0005254927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002783779,"about_ca_system_score_gemma":0.0005430019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002278836,"about_ca_topic_score_gemma":0.004213829,"domain_scores_codex":[0.9995431,0.00007219493,0.00003541456,0.0001992214,0.00008070011,0.00006951088],"domain_scores_gemma":[0.9993361,0.0002376633,0.0002311952,0.00006693105,0.00005621741,0.00007183587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002905673,0.0001636569,0.5925782,0.0008876672,0.002626116,0.001657927,0.0002562777,0.002301347,0.315315,0.0008792244,0.002767358,0.07766168],"study_design_scores_gemma":[0.0001591829,0.0005359001,0.9361595,0.00007427188,0.001648305,0.002000441,0.0001257524,0.005306772,0.04403407,0.001197101,0.008718757,0.0000398981],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670803,0.003366146,0.01032042,0.0002295658,0.00003731827,0.0001054863,0.01644224,0.0004053462,0.002013074],"genre_scores_gemma":[0.9830168,0.0005093395,0.007215137,0.000167757,0.00002909701,0.00006762169,0.008202688,0.00004035873,0.0007512568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004706512,"threshold_uncertainty_score":0.01574481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0267738622331331,"score_gpt":0.2711670438936366,"score_spread":0.2443931816605035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}