{"id":"W4377104678","doi":"10.1021/acsomega.3c02259","title":"Imidazopyridine Amides: Synthesis, <i>Mycobacterium smegmatis</i> CIII<sub>2</sub>CIV<sub>2</sub> Supercomplex Binding, and In Vitro Antimycobacterial Activity","year":2023,"lang":"en","type":"article","venue":"ACS Omega","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Deutscher Akademischer Austauschdienst; Canada Research Chairs; Canadian Institute for Advanced Research","keywords":"Mycobacterium smegmatis; Antimycobacterial; In vitro; Imidazopyridine; Mycobacterium tuberculosis; Chemistry; Mechanism of action; Biochemistry; Amide; Stereochemistry; Tuberculosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001143376,0.0008438142,0.001530402,0.001351824,0.0003318498,0.0003640734,0.0004436969,0.0005055355,0.00005760616],"category_scores_gemma":[0.002033806,0.0008154685,0.0003019487,0.001920625,0.0003864197,0.0009812386,0.0006497876,0.0009176114,0.0007373244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003617838,"about_ca_system_score_gemma":0.0003584271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002161923,"about_ca_topic_score_gemma":0.0001682231,"domain_scores_codex":[0.9942565,0.0004129069,0.0009056473,0.001356376,0.001085182,0.001983369],"domain_scores_gemma":[0.9959509,0.001496915,0.0002371953,0.001096899,0.0002223716,0.0009956956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002438823,0.0004181781,0.0391335,0.0006384149,0.0001700345,0.0007426278,0.0001688534,0.000001161393,0.9376951,0.00001384812,0.005971361,0.01260813],"study_design_scores_gemma":[0.002387505,0.0002194662,0.2325638,0.0003938432,0.0001266267,0.0001806998,0.0000797094,0.0001430067,0.7622976,0.00004412282,0.0009593993,0.0006042752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939277,0.0001681884,0.000007038601,0.002110933,0.0007723003,0.001330812,0.0008411441,0.0005608124,0.0002811308],"genre_scores_gemma":[0.9920902,0.005291428,0.0000887741,0.000315494,0.0009302555,0.000478519,0.0005881959,0.0001858737,0.00003125234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1934303,"threshold_uncertainty_score":0.9994296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02126451075339435,"score_gpt":0.2673607365810267,"score_spread":0.2460962258276323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}