{"id":"W4377104678","doi":"10.1021/acsomega.3c02259","title":"Imidazopyridine Amides: Synthesis, <i>Mycobacterium smegmatis</i> CIII<sub>2</sub>CIV<sub>2</sub> Supercomplex Binding, and In Vitro Antimycobacterial Activity","year":2023,"lang":"en","type":"article","venue":"ACS Omega","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Deutscher Akademischer Austauschdienst; Canada Research Chairs; Canadian Institute for Advanced Research","keywords":"Mycobacterium smegmatis; Antimycobacterial; In vitro; Imidazopyridine; Mycobacterium tuberculosis; Chemistry; Mechanism of action; Biochemistry; Amide; Stereochemistry; Tuberculosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001348509,0.0004215745,0.0002155931,0.0001402434,0.00008153309,0.0001079543,0.0002623091,0.0002513075,0.001232019],"category_scores_gemma":[0.00018052,0.0001317608,0.0001322694,0.0001906421,0.0001204724,0.000178221,0.0001000086,0.0003299425,0.0005583711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002296775,"about_ca_system_score_gemma":0.0002542931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005988856,"about_ca_topic_score_gemma":0.0009169233,"domain_scores_codex":[0.9999397,0.00001114603,0.000005885916,0.00001191518,0.00001475327,0.00001664298],"domain_scores_gemma":[0.9999262,0.00001133865,0.00001762851,0.000007853761,0.00001436699,0.00002253289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002778651,0.00008146136,0.0001096789,0.0001554531,0.0000053976,0.0001413311,0.00002737037,0.0004737556,0.9907266,0.0001805062,0.0001585606,0.007661916],"study_design_scores_gemma":[0.00009818159,0.002503951,0.0025595,0.000009619333,0.00002006871,0.0003944934,0.00002408968,0.0006640477,0.9871827,0.00005961304,0.006468797,0.00001483978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680527,0.006299869,0.01313758,0.0002023574,0.00007518608,0.000634408,0.002007881,0.0002433591,0.009346585],"genre_scores_gemma":[0.9766308,0.004997192,0.01223735,0.00009940872,0.00002828416,0.0002127207,0.001558834,0.00003266181,0.004202722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001232019,"threshold_uncertainty_score":0.004121542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02126451075339435,"score_gpt":0.2673607365810267,"score_spread":0.2460962258276323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}