{"id":"W4377104710","doi":"10.3390/v15051189","title":"Temsavir Modulates HIV-1 Envelope Conformation by Decreasing Its Proteolytic Cleavage","year":2023,"lang":"en","type":"article","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Deutsche Forschungsgemeinschaft; Canada Foundation for Innovation; ViiV Healthcare; University of Pennsylvania","keywords":"Glycoprotein; Cleavage (geology); Biology; Viral entry; Protein subunit; Viral envelope; Cell biology; Virology; Entry inhibitor; Antibody; Glycosylation; Antibody-dependent cell-mediated cytotoxicity; Protein structure; Human immunodeficiency virus (HIV); Viral replication; Cytotoxicity; In vitro; Molecular biology; Biochemistry; Virus; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000839532,0.0001687451,0.0001784517,0.0001040011,0.00007433892,0.0002308142,0.0001299206,0.0001629815,0.001223688],"category_scores_gemma":[0.0001452984,0.00006429409,0.0001046427,0.00008257114,0.0001186076,0.00009771028,0.0000662614,0.0003583577,0.0001713507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009601888,"about_ca_system_score_gemma":0.0001068418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001771413,"about_ca_topic_score_gemma":0.0002694989,"domain_scores_codex":[0.9999434,0.00001728557,0.000005625885,0.000006958272,0.000009398879,0.0000173723],"domain_scores_gemma":[0.9999611,0.000009830258,0.000006576903,0.000005468921,0.000006520956,0.00001048883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005818879,0.0002286982,0.0002844312,0.00004398587,0.000008407437,0.000021212,0.00001230414,0.0001006984,0.9918716,0.0000842845,0.00006190438,0.006700632],"study_design_scores_gemma":[0.00006152755,0.002379802,0.007672462,0.000005963617,0.00002639709,0.0001545054,0.00002029414,0.0007803869,0.9874928,0.00003265663,0.001369584,0.00000369946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980633,0.0006715578,0.0002287018,0.00002113692,0.00001163401,0.00001206093,0.00006178656,0.00002189192,0.0009079836],"genre_scores_gemma":[0.9978703,0.0006250368,0.0004466858,0.00002987028,0.00001038752,0.00001251827,0.0001204242,0.000005699968,0.0008790742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223688,"threshold_uncertainty_score":0.004093647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03459987180713196,"score_gpt":0.2864668458163102,"score_spread":0.2518669740091782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}