{"id":"W4377107809","doi":"10.3390/toxins15050342","title":"Neutralizing Antibody Formation with OnabotulinumtoxinA (BOTOX®) Treatment from Global Registration Studies across Multiple Indications: A Meta-Analysis","year":2023,"lang":"en","type":"review","venue":"Toxins","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Dosing; Placebo; Clinical trial; Internal medicine; Meta-analysis; Incidence (geometry); Botulinum toxin; Botulinum neurotoxin; Confidence interval; Surgery; Toxin; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002515086,0.0008269186,0.004625927,0.0002435981,0.0003255163,0.00009001877,0.0002349072,0.0006605686,0.00007234946],"category_scores_gemma":[0.0001750322,0.0004647516,0.002867588,0.002621757,0.000220306,0.000189308,0.00007870421,0.0004773967,0.0002712302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004336723,"about_ca_system_score_gemma":0.0002068691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003094424,"about_ca_topic_score_gemma":0.001621324,"domain_scores_codex":[0.9963522,0.0003199907,0.00128233,0.0009640465,0.0005375622,0.0005438877],"domain_scores_gemma":[0.9972396,0.0005032851,0.001000513,0.0008993419,0.0001408363,0.0002164504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0002945941,0.00168093,0.0003030846,0.00715051,0.8497892,0.0007172959,0.00172792,0.0003438088,0.00001070157,0.000294674,0.0006633737,0.1370239],"study_design_scores_gemma":[0.00173334,0.001122956,0.0006096324,0.001045806,0.7708165,0.00008526782,0.0006967313,0.0002301344,0.000006817118,0.0002151268,0.2226671,0.0007706241],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008122831,0.9933444,0.000524415,0.0007492471,0.0001175269,0.002536754,0.001273762,0.0004396675,0.0002019855],"genre_scores_gemma":[0.002230258,0.990493,0.0005700361,0.0002108935,0.00009678632,0.0007378081,0.004660074,0.0000654829,0.0009356751],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2220037,"threshold_uncertainty_score":0.9997804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3728662831104989,"score_gpt":0.483729665518022,"score_spread":0.1108633824075231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}