{"id":"W4377107809","doi":"10.3390/toxins15050342","title":"Neutralizing Antibody Formation with OnabotulinumtoxinA (BOTOX®) Treatment from Global Registration Studies across Multiple Indications: A Meta-Analysis","year":2023,"lang":"en","type":"review","venue":"Toxins","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Dosing; Placebo; Clinical trial; Internal medicine; Meta-analysis; Incidence (geometry); Botulinum toxin; Botulinum neurotoxin; Confidence interval; Surgery; Toxin; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02725699,0.002462582,0.01130098,0.003833225,0.0004934843,0.003373756,0.001973349,0.001647723,0.002455322],"category_scores_gemma":[0.03410726,0.001363336,0.04916535,0.00559159,0.0006067467,0.001467455,0.001718614,0.001661509,0.0003376561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001299928,"about_ca_system_score_gemma":0.001366389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004162173,"about_ca_topic_score_gemma":0.005686972,"domain_scores_codex":[0.9776357,0.01183307,0.005014962,0.003130414,0.00183597,0.0005498078],"domain_scores_gemma":[0.9675297,0.02348298,0.004203873,0.002833217,0.001627821,0.0003224529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003552929,0.00001400716,0.01384759,0.03327546,0.9411641,0.0001024066,0.00004004367,0.0007444801,0.0003678195,0.00008720579,0.0004917612,0.006312105],"study_design_scores_gemma":[0.000461636,0.0001615162,0.01070807,0.001345193,0.9857101,0.0001027794,0.0000211419,0.0002370983,0.0001555332,0.0001350401,0.0009469162,0.00001497496],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06806841,0.9209473,0.004123019,0.0005425471,0.0004564094,0.0003280658,0.00430659,0.0001339302,0.001093758],"genre_scores_gemma":[0.8624284,0.1274974,0.003195961,0.001217043,0.0003298665,0.0006114887,0.004027636,0.0001607043,0.0005314353],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02725699,"threshold_uncertainty_score":0.1441505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3728662831104989,"score_gpt":0.483729665518022,"score_spread":0.1108633824075231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}