{"id":"W4377108278","doi":"10.3390/v15051185","title":"Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC","year":2023,"lang":"en","type":"article","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"SLAC National Accelerator Laboratory; Biological and Environmental Research; Basic Energy Sciences; National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institute on Drug Abuse; National Institute of Diabetes and Digestive and Kidney Diseases; Office of Science; National Institutes of Health; National Heart, Lung, and Blood Institute; U.S. Department of Energy","keywords":"Antibody-dependent cell-mediated cytotoxicity; Epitope; Piperidine; Antibody; Chemistry; Cytotoxicity; Virology; Human immunodeficiency virus (HIV); Biology; Biochemistry; Immunology; Stereochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007330572,0.0002409149,0.0001525183,0.0001017865,0.00007541242,0.0001093645,0.0001675201,0.0001634304,0.001020649],"category_scores_gemma":[0.00008610913,0.00009724736,0.0001135053,0.00006646322,0.0001148236,0.0001640765,0.0001233295,0.0003340757,0.0001632298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001913034,"about_ca_system_score_gemma":0.0001076803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002802356,"about_ca_topic_score_gemma":0.0004987937,"domain_scores_codex":[0.9999592,0.000007318023,0.000002763725,0.000008049342,0.000009839168,0.00001282312],"domain_scores_gemma":[0.9999686,0.000006117802,0.000009661559,0.000003410289,0.000003730625,0.000008502423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000169851,0.00006394733,0.000188452,0.00007169059,0.000005547599,0.00009199901,0.00002191838,0.0005781109,0.9926599,0.0002275122,0.00007078911,0.005850376],"study_design_scores_gemma":[0.00008142793,0.002588428,0.00187327,0.00001064896,0.00001949036,0.0005442995,0.00001873275,0.001720549,0.9879297,0.00007378998,0.0051307,0.000009158082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934887,0.001819609,0.00190804,0.00007327439,0.00001330079,0.00005810955,0.0001171891,0.00004946583,0.002472466],"genre_scores_gemma":[0.9946705,0.001035669,0.002668791,0.00006403415,0.000008479898,0.00002360279,0.0001473826,0.000005154672,0.001376372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001020649,"threshold_uncertainty_score":0.003414392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0326918693787647,"score_gpt":0.2863309623724941,"score_spread":0.2536390929937293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}