{"id":"W4377108278","doi":"10.3390/v15051185","title":"Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC","year":2023,"lang":"en","type":"article","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"SLAC National Accelerator Laboratory; Biological and Environmental Research; Basic Energy Sciences; National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institute on Drug Abuse; National Institute of Diabetes and Digestive and Kidney Diseases; Office of Science; National Institutes of Health; National Heart, Lung, and Blood Institute; U.S. Department of Energy","keywords":"Antibody-dependent cell-mediated cytotoxicity; Epitope; Piperidine; Antibody; Chemistry; Cytotoxicity; Virology; Human immunodeficiency virus (HIV); Biology; Biochemistry; Immunology; Stereochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002689625,0.0002253021,0.0003196971,0.0002990273,0.0004393367,0.0000493874,0.0001726021,0.0001271302,0.0009885246],"category_scores_gemma":[0.0001465383,0.0001906351,0.00008490541,0.0005017596,0.0001115743,0.00009545954,0.0001801647,0.0002678087,0.05807048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006101589,"about_ca_system_score_gemma":0.0000640965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004555237,"about_ca_topic_score_gemma":0.0000798255,"domain_scores_codex":[0.9982579,0.00034359,0.0002330891,0.0003811218,0.0000672222,0.0007170692],"domain_scores_gemma":[0.9989437,0.0004915136,0.00003964244,0.0003636683,0.00006511087,0.00009632737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001180374,0.0001345901,0.00161351,0.0000147961,0.0001697338,0.0001608347,0.0003669028,0.00004528484,0.9278492,0.00006523116,0.06612282,0.003339058],"study_design_scores_gemma":[0.0009087009,0.0002936595,0.00328875,0.00003183689,0.00002514291,0.0000311372,0.0001878983,0.00000614244,0.7650827,0.00002164063,0.2299323,0.0001900753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953514,0.0008778938,0.00005408106,0.0004646025,0.0005257613,0.0003633364,0.0003438152,0.000440944,0.001578171],"genre_scores_gemma":[0.9922217,0.0002203932,0.0001484728,0.0004071404,0.0000721317,0.00006890853,0.0003582264,0.00003344335,0.006469612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1638095,"threshold_uncertainty_score":0.9999247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0326918693787647,"score_gpt":0.2863309623724941,"score_spread":0.2536390929937293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}