{"id":"W4377115628","doi":"10.1371/journal.pbio.3001822","title":"Candida albicans selection for human commensalism results in substantial within-host diversity without decreasing fitness for invasive disease","year":2023,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; National Human Genome Research Institute; University of Michigan","keywords":"Biology; Commensalism; Candida albicans; Corpus albicans; Microbiology; Host (biology); Virulence; Population; Pathogen; Genetic diversity; Genetics; Bacteria; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001943936,0.0002456747,0.0003179216,0.0002815467,0.0001961821,0.0004003219,0.0001923557,0.0001844631,0.001591437],"category_scores_gemma":[0.0002917809,0.00009079115,0.0001759018,0.0002656036,0.0002961654,0.00009164288,0.0002869419,0.0003781517,0.0002032358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002073822,"about_ca_system_score_gemma":0.000319063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008435007,"about_ca_topic_score_gemma":0.001658757,"domain_scores_codex":[0.999674,0.0000569986,0.00001695766,0.00006948644,0.0001194672,0.00006323429],"domain_scores_gemma":[0.9997997,0.00003774951,0.00004288944,0.00003040391,0.00002166061,0.00006754621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002506671,0.00004486724,0.004301774,0.00002336538,0.0000180139,0.0001200705,0.00002371396,0.00009169524,0.991482,0.0001218532,0.0000755085,0.003446517],"study_design_scores_gemma":[0.00006078097,0.001632066,0.1932612,0.00003154933,0.00008299016,0.003313304,0.0002549069,0.002365615,0.7945523,0.000319863,0.004086887,0.00003854508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983947,0.0003750725,0.000401436,0.00005578742,0.000006098638,0.000006778497,0.0001273896,0.00002424142,0.0006085682],"genre_scores_gemma":[0.9987733,0.0001317718,0.000551938,0.00003602121,0.000004025816,0.000005144104,0.0001136925,0.000008520222,0.0003755503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001591437,"threshold_uncertainty_score":0.005323887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07588450280281343,"score_gpt":0.3445004338570925,"score_spread":0.2686159310542791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}